Non-syndromic and syndromic keratocystic odontogenic tumors: Systematic review and meta-analysis of recurrences

Antonoglou, Georgios N.; Sándor, George K.B.; Koidou, Vasiliki P.; Papageorgiou, Spyridon N.

doi:10.1016/j.jcms.2014.03.020

Cited by 61 publications

(39 citation statements)

References 39 publications

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“…19 A lack of studies on the treatment of OKC associated with NBCCS has been confirmed in a recent systematic review, 23 which indicates that minimal evidence exists on this specific type of OKC. Therefore, the evaluation of treatments for OKCs associated with NBCCS is necessary.…”

Section: Introductionmentioning

confidence: 99%

Reclassification and treatment of odontogenic keratocysts: A cohort study

et al. 2017

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The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the cohort of patients included in the present study consisted of 40 OKCs, of which 27 lesions were treated by enucleation (GE) and 13 underwent decompression (GD). Complementary treatment occurred in 38 (95%) lesions, of which 10 underwent isolated peripheral ostectomy (GO) and 28 underwent peripheral ostectomy combined with Carnoy's solution (GC). Thirteen lesions were associated with NBCCS (GS), while the others (n=27) were non-syndromic lesions (GnS). The recurrence-free periods (RFP) in the sample groups were compared using the Kaplan-Meier function and log-rank test at a significance level of 5% (p < 0.05) and were used to calculate the cumulative risk of recurrence (CRR) in each postoperative year. During the follow-up period, which had a mean of 43.5 months (range: 12-102 months), six (15%) recurrences were diagnosed. There was no significant difference among the RFP for the compared groups (p > 0.05) or increased CRR for the decompression (15.4%) over five years. Application of Carnoy's solution did not increase the efficacy of the peripheral ostectomy, but was related to a CRR of 0% for the syndromic lesions over five years. Therefore, 1) decompression did not increase the recurrence risk; 2) peripheral ostectomy demonstrated a similar efficacy as the combination with Carnoy's solution; 3) the association of NBCCS did not seem to significantly influence OKC recurrence; and 4) syndromic lesions seem to behave in the same manner as non-syndromic lesions when submitted to complementary treatments.

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Section: Introductionmentioning

confidence: 99%

Reclassification and treatment of odontogenic keratocysts: A cohort study

et al. 2017

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“…We encountered a case of multiple odontogenic cysts in a NFNS patient, but no previous reports have described cases showing similar conditions. NBCCS is the most common syndrome presenting with multiple jaw cysts, which histopathologically represent KCOTs [4]. Other than NBCCS, orofacial digital syndrome [5], Ehler-Danlos syndrome [6], Simpson-Golabi-Behmel syndrome [7] and NS [8] can present with multiple KCOTs reportedly in English written literatures, though only a single case report has been reported for each.…”

Section: Discussionmentioning

confidence: 99%

Multiple odontogenic cysts in a patient with Neurofibromatosis–Noonan syndrome

Yamashita

Fujita

Ikeda

et al. 2016

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Neurofibromatosis-Noonan syndrome (NFNS) is an uncommon chromosomal disordershowing features of both neurofibromatosis (NF-1) and Noonan syndrome (NS). We encountered a case of NFNS with keratocystic odontogenic tumor and dentigerous cysts. A 19-year-old Japanese girl was referred to our hospital with a chief complaint of swelling in the left side of the mandible. The patient showed symptoms of both NF-1, in the form of café-au-lait spots and neurofibromatosis, and NS, in the form of short stature, intellectual disturbance, webbed neck, and hypertelorism. Panoramic radiography showed three cystic lesions, one on each side of the mandible and one on the left side of the maxilla. All cysts were removed surgically under general anesthesia. Histopathological examination revealed that both mandibular cysts were dentigerous cysts, while the maxillary cyst was a keratocystic odontogenic tumor. No recurrence has been seen as of 5 years postoperatively. Multiple jaw cysts might be added as a potential finding in NFNS.2

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“…In general, KCOT is a pathological entity with aggressive behavior and a high rate of recurrence (1). In 2005, the World Health Organization revised and updated the classification of odontogenic tumors as well as certain associated terminologies (8).…”

Section: Discussionmentioning

confidence: 99%

“…Keratocystic odontogenic tumors (KCOTs) are locally aggressive benign tumors which occur in the bones of both jaws with a high recurrence rate (1). They may occur at any age with a peak in the second and third decades of life (2).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous occurrence of keratocystic odontogenic tumor and ameloblastoma in the mandible: A case report

et al. 2015

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Abstract. Keratocystic odontogenic tumors (KCOTs) and ameloblastomas are benign odontogenic tumors that primarily occur in the molar region of the mandible. However, it is uncommon for these tumors to arise simultaneously in a patient's jaw. The present study reported the diagnostic process and features of a rare case of the simultaneous occurrence of KCOT and ameloblastoma in the mandible of a 45-year-old male. Image-based diagnosis was challenging due to several conditions, including the intactness of the teeth and bone cortex as well as the sizes and locations of the lesions. Based on radiographic evidence, the patient was initially misdiagnosed and underwent a biopsy for a radicular cyst and a simple bone cyst prior to the correct diagnoses of KCOT and ameloblastoma, respectively. In addition, the present study discussed the diagnostic process of the present case and reviewed previous literature regarding the simultaneous occurrence of benign tumors of the jaw.

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Non-syndromic and syndromic keratocystic odontogenic tumors: Systematic review and meta-analysis of recurrences

Cited by 61 publications

References 39 publications

Reclassification and treatment of odontogenic keratocysts: A cohort study

Reclassification and treatment of odontogenic keratocysts: A cohort study

Multiple odontogenic cysts in a patient with Neurofibromatosis–Noonan syndrome

Simultaneous occurrence of keratocystic odontogenic tumor and ameloblastoma in the mandible: A case report

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