Non-Thermal Atmospheric Dielectric Barrier Discharge Plasma, Medical Application Studies in Thailand

Abstract

Atmospheric Dielectric Barrier Discharge (DBD) plasma development is one of the most interesting subjects to our group. Fridman et al. * has concluded that Floating DBD Direct Plasma are more effective in bactericidal property, it contains higher free charged particles than indirect type. DBD plasma sources can provide low temperature or non-thermal (cold) plasmas, and these plasmas can be created with ambient air or with a noble gas, such as helium or argon, as the carrier medium. It can be used with an electrode as a contact or noncontact method to target a tissue. However, the drawback of direct DBD plasma is that it will work only in short gap distances, on the order of a few millimeters. Our group has investigated -PLASMA Cell Modulation: PhotoBioCare, Thailand). The major area has been focused on its bactericidal disinfection property, application in common dermatologic problems, in skin aesthetic facial rejuvenation and chronic wound management, from 2012 to 2016.

A novel treatment approach for traumatic scalp defects with exposed calvaria denuded of pericranium by combined application of low‐temperature plasma and negative pressure wound therapy: A case series

“…The BioPlasmaJet BPJ1 system (BIOPlasma System: Model‐BioPlasmaJet System, BioPhotoCare Co., Ltd.) is a novel LTP device that uses cold plasma jets to treat wounds. The device generates an LTP field with an intermediate effective dose (2–6 J/cm 2 ) and has been shown to induce angiogenesis, promote cell proliferation, reduce inflammation, and exert an antimicrobial effect 7–9 . This is a potential wound care option for patients with non‐healing wounds, such as pressure ulcers, diabetic ulcers, and chronic wounds.…”

“…Low‐temperature plasma therapy (LTP) is a novel treatment modality that promotes wound healing by inducing angiogenesis and promoting cell proliferation and migration via intracellular signaling pathways. Moreover, it has been shown to reduce inflammation and exhibit antimicrobial properties via lipid peroxidation 6–9 …”

“…Moreover, it has been shown to reduce inflammation and exhibit antimicrobial properties via lipid peroxidation. [6][7][8][9] In this case series, I describe my experience using a combination of NPWT and LTP after cortical craniectomies to promote granulation tissue formation, prevent local infection of traumatic scalp defects with exposed calvaria denuded of the pericranium, and potentially decrease the duration of NPWT in three patients.…”

“…Moreover, it has been shown to reduce inflammation and exhibit antimicrobial properties via lipid peroxidation. 6 , 7 , 8 , 9…”

Argon Atmospheric Plasma Treatment Promotes Burn Healing by Stimulating Inflammation and Controlling the Redox State

“…Due to being pro-sterilizing, the components released by plasma torches have shown potential for use in several therapeutic applications, mainly directly related to inducing the healing process [2][3][4]. Several applications have been investigated using plasma, such as blood coagulation [5], immune system modulation and blocking tumor proliferation [6], macular degeneration [7], tissue sterilization [8], acne healing [9], eczema [10], venous ulcers [11], chronic lower limb ulcers [12], and skin rejuvenation [13].…”