Non-thermal atmospheric pressure plasma functionalized dental implant for enhancement of bacterial resistance and osseointegration

Lee, Jung Hwan; Jeong, Won Seok; Seo, Seog Jin; Kim, Hae Won; Kim, Kyoung Nam; Choi, Eun Ha; Kim, Kwang Mahn

doi:10.1016/j.dental.2016.11.011

Cited by 66 publications

(44 citation statements)

References 67 publications

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“…Plasma treatment has been reported to break C-C bonds and C-H bonds of zirconia surface, remove the contaminant, and increase oxygen atoms and decrease carbon atoms [ 39 , 43 , 44 ]. These changes in the surface properties can increase the hydrophilicity and thus improving the wettability of the primer or resin cement [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement

et al. 2020

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The purpose of this study was to investigate the effect of non-thermal atmospheric pressure plasma (NTP) treatment on the sandblasting of mechanical method and zirconia primer of chemical method used to increase the bond strength between zirconia and resin cement. In this study, Y-TZP was divided into 4 groups according to the surface treatment methods as follows: Zirconia primer (Pr), NTP + Zirconia primer (NTP + Pr), Sandblasting + Zirconia primer (Sb + Pr), Sandblasting + NTP + Zirconia primer (Sb + NTP + Pr). Then, two types of resin cement (G-CEM LinkAce and Rely X-U200) were used to measure the shear bond strength (SBS) and they were divided into non-thermal cycling group and thermal cycling group for aging effect. Statistical analyses were performed using the Kruskal-Wallis test and Mann-Whitney U test. The result of the surface energy (SE), there was no significant difference among the groups (p > 0.05). As a result of the SBS test, the Sb + Pr group had a significantly higher SBS value than the other groups regardless of the resin cement type (p < 0.05), and the decrease rate after thermal cycling treatment was the lowest. On the other hand, the NTP + Pr group showed significantly lower SBS values than the other groups except for the case of using Rely X-U200 (p < 0.05), and the reduction rate after thermal cycling was the highest. The Sb + NTP + Pr group did not differ significantly from the Pr group (p > 0.05). Within the limitations of two successive studies, treatment with NTP after sandblasting used for mechanical bond strength showed a positive effect on initial SBS. However, when NTP was treated before the zirconia primer used for the chemical bond strength, it showed a negative effect on SBS compared to other treatment methods, which was noticeable after the thermal cycling treatment.

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Section: Discussionmentioning

confidence: 99%

Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement

et al. 2020

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“…Localized infection is the main cause of implant failure [21]; therefore, the induction of antimicrobial properties on implant surfaces is considered beneficial. Implant materials with an antimicrobial interface promote the growth and proliferation of cells and inhibit the adhesion and expansion of bacteria [22]. Cell adhesion and a cellbiomaterial interface are complicated processes associated with a number of factors [23,24] such as cell biological behaviors and material surface properties as well as environmental factors including hydrophilicity, charge, roughness, hardness, and chemical composition [25].…”

Section: Discussionmentioning

confidence: 99%

Biofunctionalization of Microgroove Surfaces with Antibacterial Nanocoatings

Lai¹,

Chen

et al. 2020

BioMed Research International

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Objectives. To investigate the physical properties of the modified microgroove (MG) and antibacterial nanocoated surfaces. In addition, the biological interactions of the modified surfaces with human gingival fibroblasts (HGFs) and the antibacterial activity of the surfaces against Porphyromonas gingivalis were studied. Methods. The titanium nitride (TiN) and silver (Ag) coatings were deposited onto the smooth and MG surfaces using magnetron sputtering. A smooth titanium surface (Ti-S) was used as the control. The physicochemical properties including surface morphology, roughness, and hydrophilicity were characterized using scanning electron microscopy, atomic force microscopy, and an optical contact angle analyzer. The “contact guidance” morphology was assessed using confocal laser scanning microscopy. Cell proliferation was analyzed using the Cell Counting Kit-8 assay. The expression level of the main focal adhesion-related structural protein vinculin was compared using quantitative reverse transcription PCR and Western blotting. The antibacterial activity against P. gingivalis was evaluated using the LIVE/DEAD BacLight™ Bacterial Viability Kit. Results. The Ag and TiN antibacterial nanocoatings were successfully deposited onto the smooth and MG surfaces using magnetron sputtering technology. TiN coating on a grooved surface (TiN-MG) resulted in less nanoroughness and greater surface hydrophilicity than Ag coating on a smooth surface (Ag-S), which was more hydrophobic. Cell proliferation and expression of vinculin were higher on the TiN-MG surface than on the Ag-coated surfaces. Ag-coated surfaces showed the strongest antibacterial activity, followed by TiN-coated surfaces. Conclusion. Nano-Ag coating resulted in good antimicrobial activity; however, the biocompatibility was questionable. TiN nanocoating on an MG surface showed antibacterial properties with an optimal biocompatibility and maintained the “contact guidance” effects for HGFs.

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“…Za CAP metodu utvrđen je manji porast temperature u odnosu na konvencionalne metode, što znači da se uporabom CAP-a u svrhu izbjeljivanja zubi smanjuje mogućnost oštećenja potpornog aparata zubi i/ili zubne pulpe 74 . Iz navedenih primjera vidimo da je primjena CAP-a u stomatološkim in vitro studijama do sada dala vrlo obećavajuće rezultate, no za stvarnu procjenu uspješnosti tretmana CAP-om nedostaju detaljna in vivo istraživanja 75 .…”

Section: Stomatologijaunclassified

Plasma applications in medicine and dentistry

Mance

2017

Med. flum.

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Sažetak. U fizici, plazma je ioniziran, kvazineutralan plin za koji se često kaže da je četvrto stanje materije. Dugo vremena se plazma u medicini koristila zbog svojih termalnih svojstava, primjerice za sterilizaciju kirurškog i medicinskog pribora te za rezanje i kauterizaciju tkiva. Generiranjem hladne plazme u atmosferskim uvjetima započelo je novo razdoblje u primjeni plazme u biomedicini. Plazma medicina novo je interdisciplinarno znanstveno područje koje kombinira spoznaje fizike plazme s biomedicinskim i kliničkim znanostima. Hladna atmosferska plazma emitira elektromagnetno zračenje te se sastoji od mnoštva nabijenih i nenabijenih čestica, među kojima su najznačajnije reaktivne kisikove i dušikove vrste. Smatra se da su upravo reaktivne kisikove vrste najvažnije za biološke učinke plazme kao što su inaktivacija mikroorganizama i biofilmova. U dermatologiji se pokazalo da hladna atmosferska plazma pozitivno utječe na zacjeljivanje kroničnih rana. Prvi instrumenti za primjenu hladne plazme na ljudima već su i komercijalno dostupni. Primjena hladne plazme ima velik potencijal za primjenu u onkologiji, ali i u stomatologiji. Mnogobrojne studije dale su vrlo obećavajuće rezultate za primjenu hladne plazme u medicini, no treba imati na umu da mehanizmi međudjelovanja plazme s biološkim tkivom još uvijek nisu u potpunosti razjašnjeni, da nema dogovorom prihvaćene definicije doze koju plazma predaje materiji, da još uvijek nema standardiziranih instrumenata za generiranje i karakterizaciju plazme te da za pravu procjenu potencijala primjene atmosferske plazme u medicini i stomatologiji nedostaje više detaljnih in vivo studija.Ključne riječi: dermatologija; onkologija; plazma; stomatologija Abstract. Physical plasma is an ionized, quasi-neutral gas. It is often said to be the fourth state of matter. For a long time, plasma was used in medicine exclusively because of its thermal properties for sterilization purposes of surgical equipment and medical supplies, and also to cut and cauterize tissue. The possibility to generate cold plasma in atmospheric conditions marked the beginning of a completely new era in the application of plasma in biomedicine. Plasma medicine is a new interdisciplinary field of science that combines the knowledge of plasma physics to biomedical and clinical sciences. Cold atmospheric plasma emits electromagnetic radiation and it consists out of charged and uncharged particles, among those reactive oxygen and nitrogen species are the most important ones. It is considered that reactive oxygen species cause the most important biological plasma effects, such as inactivation of microorganisms and biofilms. It has been shown in dermatology that cold atmospheric plasma has a healing effect on chronic wounds. First instruments for the application of cold plasma in humans are already commercially available. Cold plasma has a great potential for application in oncology and in dentistry. Numerous studies have yielded very promising results for the application of cold plasma in medicine, but it should ...

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Non-thermal atmospheric pressure plasma functionalized dental implant for enhancement of bacterial resistance and osseointegration

Cited by 66 publications

References 67 publications

Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement

Effect of Non-Thermal Atmospheric Pressure Plasma (NTP) and Zirconia Primer Treatment on Shear Bond Strength between Y-TZP and Resin Cement

Biofunctionalization of Microgroove Surfaces with Antibacterial Nanocoatings

Plasma applications in medicine and dentistry

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