Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Zheng, Jia; Sun, Zhaoqing; Zhang, Xingang; Zhao, Li; Guo, Xiaofan; Xie, Yanxia; Sun, Yingxian; Zheng, Liqiang

doi:10.1186/s12944-019-0958-y

Cited by 27 publications

(19 citation statements)

References 50 publications

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“…Wang et al 2011also found that hemorrhagic stroke is inversely associated with plasma serum high density lipoprotein cholesterol (HDL-C) (32). A study of Zeng et al 2019 observed that serum HDL and ratio of LDL and HDL was not associated with hemorrhagic stroke (33). Similarly in our study we found non-significant negative correlation between serum HDL-C and hemorrhagic stroke.…”

Section: Resultssupporting

confidence: 64%

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Shrivastav¹,

Singh²,

Kushwaha³

et al. 2019

EJMR

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The relation between lipid profile and hemorrhagic stroke is controversial till now. Many epidemiological studies show inverse association of total cholesterol and triglycerides with hemorrhagic stroke. We analyze diagnostic role of lipid profile parameter in hemorrhagic stroke via case control study. The aim was to investigate lipid profile in hemorrhagic stroke patients and healthy control persons. Total 100 subject's case and control were included in this study and divided in two groups. 50 are hemorrhagic stroke patients and 50 are healthy control. Patients age <18, renal and hepatic impairment and familial hypercholesterolemia and hyperthyroidism were excluded. The inclusion of age group was between (64.8±11.9) and (48.9 ±9.9). Statistical analysis was done by using SPSS version 21.0. p value was calculated by ANOVA unpaired t-test. The p<0.05 was considered a statistically significant. The mean value of Total cholesterol (p=0.0001*) and Triglycerides (p=0.0254) were significantly low in hemorrhagic stroke patients compared with healthy control respectively. The mean LDL-C and VLDL-C were also significantly low in hemorrhagic stroke compared to healthy individuals (p=0.016 and p=0.025) respectively. Similarly, the mean HDL-C was also low in hemorrhagic stroke patients compare to healthy individuals. The hemorrhagic stroke patient's serum total cholesterol and triglycerides (r=-0.0854,p=0.0001 and r=-0.200 and p=0.046) were show significantly negative correlation with healthycontrol. The LDL-C and VLDL-C (r=-0.121 p=0.230 and r=-0.200, p=0.460) were show non-significant negative association in hemorrhagic stroke compare to healthy control respectively. HDL-C of hemorrhagic stroke patient's shows positively non-significantly associated with healthy control (r=0.0891, p=0.3785). This present study concluded that lipid profile levels play significant diagnostic role in hemorrhagic stroke patients. The lower concentration of total cholesterol and triglycerides may predispose individual towards the higher risk of hemorrhagic stroke.

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Section: Resultssupporting

confidence: 64%

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Shrivastav¹,

Singh²,

Kushwaha³

et al. 2019

EJMR

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“…Many randomized control trials demonstrated LDL as an important causal risk for the development of Ischemic stroke and reported an inverse association of LDL with the risk of hemorrhagic stroke [ 16 ]. Our study observed the null associations difference of LDL in hemorrhagic and ischemic stroke patients.…”

Section: Discussionmentioning

confidence: 99%

Differences of Lipid Profile Among Ischemic and Hemorrhagic Stroke Patients in a Tertiary Hospital in Riyadh, Saudi Arabia: A Retrospective Cohort Study

Alkhaneen¹,

Alsadoun²,

Almojel³

et al. 2022

Cureus

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Objective This study aims to compare the serum lipid profiles of patients with ischaemic and hemorrhagic strokes. Study design This was a retrospective, comparative study. Place and duration of the study The study was conducted at Military Hospital, Riyadh, from January 1, 2018, to December 31, 2020. Methodology Patients with a diagnosis of stroke who presented to the emergency department and was confirmed to have ischemic or hemorrhagic strokes by computed tomography (CT) from January 1, 2018, to December 31, 2020. This study was based on data extracted from an electronic hospital information system (BESTCare) of patients presenting to King Abdulaziz Medical City, National Guard Health Affairs, which is a tertiary medical center in Riyadh, Saudi Arabia. Patients who lack lipid profile reading within six months before the incident or had a traumatic hemorrhagic stroke were excluded from the study. All these variables were included in the study: age, gender, height, weight, date of the incident, date of last lipid profile results, type of stroke, comorbidities, on a statin or not, and lipid profile including (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides). Microsoft Excel 2019 (Microsoft Corporation, Redmond, WA) was used for data entry and data cleaning, and Statistical Package for the Social Sciences (SPSS) version 23 (IBM Corp., Armonk, NY) was used for data analysis and visualization of the results. Results The mean age of presentation of stroke was 68±13, 59% of patients were males, and 41% were females. BMI ranged from 30±8. Obesity (BMI 30 or above) was predominant in both stroke subtypes. Among all patient comorbidities, hypertension was the most predominant. Diabetes was present in 71% of the population. Of the participants in this study, 114 had ischemic stroke and 87 had a hemorrhagic type. A comparison of the serum lipid profile of two categories of strokes showed no statistical significance in serum values of total cholesterol, triglycerides, and LDL-C in ischemic and hemorrhagic stroke patients.

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“…Other studies estimated that the recurrence of cerebral ischemia increases with age and the increased composition of non-traditional lipid variables values: TC/HDL-C and LDL-C/HDL-C [40]. Zheng et al showed that LDL-C, non-HDL-C and LDL-C/HDL-C are associated with the future all stroke status, and TC, LDL-C, non-HDL-C, TC/HDL-C and LDL-C/HDL-C are associated with the future ischemic stroke state [41]. Other studies show a positive relationship between cholesterol levels and the risk of IS in men, while an inverse trend between TC and the risk of hemorrhagic stroke is observed in the female group.…”

Section: Non-traditional Lipid Profiles As Stroke Predictorsmentioning

confidence: 99%

Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke

Kłoska

Malinowska

Gabig-Cimińska

et al. 2020

IJMS

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Stroke is a severe neurological disorder in humans that results from an interruption of the blood supply to the brain. Worldwide, stoke affects over 100 million people each year and is the second largest contributor to disability. Dyslipidemia is a modifiable risk factor for stroke that is associated with an increased risk of the disease. Traditional and non-traditional lipid measures are proposed as biomarkers for the better detection of subclinical disease. In the central nervous system, lipids and lipid mediators are essential to sustain the normal brain tissue structure and function. Pathways leading to post-stroke brain deterioration include the metabolism of polyunsaturated fatty acids. A variety of lipid mediators are generated from fatty acids and these molecules may have either neuroprotective or neurodegenerative effects on the post-stroke brain tissue; therefore, they largely contribute to the outcome and recovery from stroke. In this review, we provide an overview of serum lipids associated with the risk of ischemic stroke. We also discuss the role of lipid mediators, with particular emphasis on eicosanoids, in the pathology of ischemic stroke. Finally, we summarize the latest research on potential targets in lipid metabolic pathways for ischemic stroke treatment and on the development of new stroke risk biomarkers for use in clinical practice.

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Non-traditional lipid profiles associated with ischemic stroke not hemorrhagic stroke in hypertensive patients: results from an 8.4 years follow-up study

Cited by 27 publications

References 50 publications

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Diagnostic Value of Lipid Profile in Hemorrhagic Stroke Patients

Differences of Lipid Profile Among Ischemic and Hemorrhagic Stroke Patients in a Tertiary Hospital in Riyadh, Saudi Arabia: A Retrospective Cohort Study

Lipids and Lipid Mediators Associated with the Risk and Pathology of Ischemic Stroke

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