“…The development of necrosis and cavitation in a primary bronchial carcinoma depends to a large extent on the site and histological type of the growth. Koletsky (1938), Gray et al (1951, Laforet and Laforet (1957), Bernhard et al (1962), and others indicated that the frequency of cavity formation increases with the histological grade of malignancy and the excavation is more likely to develop in large, widely infiltrating, peripheral carcinomas. In most series, including Davidson (1930), Edwards (1938), Brock (1952), Strang andSimpson (1953), Farber (1954), Hinshaw and Garland (1966), and Spencer (1968), squamous-cell carcinomas and undifferentiated carcinomas of large polygonal-cell type were found to be associated with necrosis and eventual cavitation more often than similarly situated adenocarcimomas.…”