Non‐ulcerative Basal Cell Carcinoma

Takahashi, Hiroyuki

doi:10.1111/j.1346-8138.2000.tb02285.x

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…Genital BCCs tend to develop in an older age group, with similar mean age at presentation for women (mean 71 years) and men (mean 69.9 years) in this cohort. Male sex is one risk factor for BCC outside the genitalia, while genital BCCs are predominantly reported in females in previous literature (16,17). Similarly, in this study, the majority of patients with genital E-H).…”

Section: Discussionsupporting

confidence: 66%

“…The reason for this female predominance remains to be clarified. One possible explanation is the presence of a chronic skin irritation such as chronic vulvovaginitis, since most patients with vulvar BCC tend to be postmenopausal with drastically reduced hormone levels (16). Despite the higher incidence, females had better DSS than males, and the cause remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

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Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

et al. 2021

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IntroductionBasal cell carcinoma (BCC) located on the genitalia is rare; data on the clinicopathologic features and survival outcomes are only available through case reports and small case series studies.PurposeThis study aimed to explore the epidemiology and identify the prognostic factors of genital BCCs.MethodsWe queried the 18 registries of the Surveillance, Epidemiology, and End Results database for patients with primary BCCs of the genital skin from 2000 through 2017. The primary endpoint was overall survival (OS) and disease specific survival (DSS). Kaplan-Meier survival analysis was conducted to assess the impact of clinicopathological variables on OS and DSS. Multivariate Cox proportional hazards model was performed to evaluate risk factors for OS.ResultsA total of 1,607 cases of genital BCCs were identified. The cohort was composed of 1,352 women (84.1%) and 255 men (15.9%). The median (P25, P75) age of the entire cohort was 73(63–82)years. White patients accounted for 87.2% of the cases. For women and men, the most common site of involvement was the labia majora (89.6%) and scrotum (74.5%), respectively. The majority of patients with genital BCC had localized disease (75.5%). Kaplan-Meier survival analysis showed that female genital BCCs experienced better DSS than men (209.1 months vs 194.8 months); for men, BCCs located on the scrotum had better DSS and OS than those on the penis (P < 0.05 for both endpoints). All patients with distant disease died of disease-specific death, and the average survival time was 8.2 months. Multivariate analysis revealed that age, primary site, and stage were independent determinants of OS for men, while tumor size, histologic subtype, and race were not. For women, factors associated with worse OS included increasing age, tumor size more than 2 cm, and distant disease; factors associated with a decreased risk included “other” and “unknown” races.ConclusionThe prognosis of genital BCCs is excellent, while the survival of distant disease is very poor. Despite similar clinicopathologic features and overall survival outcomes, men and women should be treated as two different entities when making survival predictions.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

et al. 2021

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“…Other etiologic factors must be considered when BCC appears in sun‐protected skin such as the perianal and genital regions. Previous studies suggested that BCC in the perianal or genital regions may be a result of nonspecific factors such as generalized depression of immunosurveillance due to old age, poor hygiene, local chronic skin irritation, previous radiotherapy, and exposure to arsenic and other toxic substances . In this study, all 10 cases of BCC occurred in elderly patients (median age 70) with no history of previous radiation or exposure to toxic substances.…”

Section: Discussionmentioning

confidence: 99%

Basal Cell Carcinoma of the Scrotum: Clinicopathologic Analysis of 10 Cases

Dai

Kong

et al. 2012

Dermatologic Surgery

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“…In most case reports, lesion size, specific anatomic site, patient age, treatment, recurrence, associated metastases, and provider specialty were available. These data were noted and tabulated yielding 96 reports in the English literature describing 437 patients with BCCs of the vulva . Of the 96 reports, 41 were published in the gynecology or gynecologic oncology literature, 29 in the dermatology literature, and 26 in nongynecology, nondermatology literature (pathology, surgery, oncology, medicine).…”

Section: Literature Review: Materials and Methodsmentioning

confidence: 99%

Basal cell carcinoma of the vulva: a case report and systematic review of the literature

et al. 2018

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The vulva is an unusual site for basal cell carcinoma (BCC). Vulvar BCC accounts for <1% of all BCCs and <5% of all vulvar malignancies. We report the case of an 83 year-old woman who presented with a 2-month history of a tender labial growth, with histopathology confirming nodular BCC. We conducted a systematic literature review of the characteristics of reported cases of vulvar BCCs. A comprehensive systematic review of articles indexed for MEDLINE and Embase yielded 96 reports describing 437 patients with 446 BCCs of the vulva. The mean age at presentation was 70 (range 20-100). Most women had no underlying vulvar disease. Approximately 60% of cases were of the nodular subtype.Treatment approach varied widely with over half of cases treated with wide local or local excision. Mohs micrographic surgery (MMS) for vulvar BCC was first reported in 1988 with seven total MMS cases reported. Twenty-three cases of recurrence have been reported; 21 of these cases after local excision but none following MMS. Vulvar BCC is a rarely reported cancer that affects older women predominantly. MMS represents a promising treatment for BCC in this anatomic location. Case ReportAn 83-year-old woman with a 40-year history of treated lichen sclerosus presented with a tender growth in the genital area for 2 months. Genital examination revealed a 5-mm eroded papule on the right inferolateral labium majus arising on normal skin, and a white, sclerotic appearance of the labia minora and clitoris ( Fig. 1). Biopsy of the papule revealed a nodular BCC.The patient underwent MMS. She has no evidence of disease recurrence at 3 years.

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Non‐ulcerative Basal Cell Carcinoma

Cited by 13 publications

References 15 publications

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis

Basal Cell Carcinoma of the Scrotum: Clinicopathologic Analysis of 10 Cases

Basal cell carcinoma of the vulva: a case report and systematic review of the literature

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