Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution

O’Mahony, Aoife; Godinho, Bruno M.D.C.; Cryan, John F.; O’Driscoll, Caitriona M.

doi:10.1002/jps.23672

Cited by 49 publications

(49 citation statements)

References 181 publications

(341 reference statements)

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“…TEM results demonstrated that poly (I:C) binding improves the dispersivity of DcMNPs and prevents their agglomeration. DcMNPs can be targeted to the specific cancer cells by its magnetic core in the presence of magnetic field [1,2].…”

Section: Discussionmentioning

confidence: 99%

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Khodadust¹,

Ünsoy²,

Gündüz³

2014

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Khodadust¹,

Ünsoy²,

Gündüz³

2014

Biomedicine & Pharmacotherapy

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“…To improve safe siRNA NPs delivery to the CNS, the proper design of nanoparticles (Table 1) needs to be studied to enhance BBB crossing and endosomal escape (O'Mahony et al, 2013;PerezMartinez et al, 2012). As an example, pluronic block copolymers contain two hydrophilic PEG and one hydrophobic PPG blocks (PEG-PPG-PEG) were shown to bind to the membranes of brain microvessel endothelial cells (Gilmore et al, 2008).…”

Section: Sirna Deliverymentioning

confidence: 99%

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

Gomes¹,

Martins²,

Sarmento³

2015

Ageing Research Reviews

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“…The BBB (substantially reviewed in Refs. [168,169]) is a highly regulated and efficient barrier that limits the access of large molecules to the CNS. Recently, multifunctional NPs have been developed to facilitate delivery of therapeutic agents across the BBB.…”

Section: Systemic Administrationmentioning

confidence: 99%

Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines?

et al. 2015

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KEYWORDS siRNA delivery, RNA interference (RNAi)-based therapeutics, multifunctional nanoparticles, nanotoxicity of gold nanoparticles ABSTRACT RNA interference (RNAi) effectors such as small interfering RNA (siRNA) and micro RNA (miRNA) can selectively downregulate any gene implicated in the pathology of a disease. Therefore, RNAi-based therapies have immense potential for the treatment of a wide range of diseases. However, pharmacokinetic and pharmacodynamic studies have revealed that these therapeutic agents have poor bioactivity due to a number of factors, including insufficient plasma drug levels, short plasma half-lives, renal clearance, and hepatic metabolism. Non-viral delivery may facilitate the clinical application of siRNA-based therapeutics by helping to overcome these barriers. Recently, the potential of gold nanoparticles (AuNPs) as multifunctional carriers for transporting drugs, proteins, and genetic materials has been demonstrated. In this review, some of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chemistry have been described. In addition, the ability of AuNP-based formulation strategies to successfully overcome delivery barriers associated with siRNA, and the potential for this material to translate into safe and effective nanomedicines are critically discussed.

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Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution

Cited by 49 publications

References 181 publications

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

siRNA as a tool to improve the treatment of brain diseases: Mechanism, targets and delivery

Biomimetic gold nanocomplexes for gene knockdown: Will gold deliver dividends for small interfering RNA nanomedicines?

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