Nonabsorbable polysaccharide-functionalized polyethylenimine for inhibiting lipid absorption

Yue, Yenan; Yadav, Shreebodh Kumar; Wang, Caijuan; Zhao, Yu; Zhang, Xinge; Wu, Zhongming

doi:10.1016/j.carbpol.2018.05.083

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…Lipid sequestration and cytotoxicity studies revealed that the hexyl‐substituted PEI‐β‐CD exhibited a lower sequestration capacity and higher cytotoxicity, presumably due to the longer chain length; butyl‐substituted PEI‐β‐CD had the highest sequestration ability. Further increasing the charge density of PEI‐β‐CD with 1‐bromobutane resulted in higher lipid affinity, while not producing any appreciable cytotoxicity or observable histological changes in mice …”

Section: Sequestration In the Gastrointestinal Tractmentioning

confidence: 99%

“…The efficacy of the PEI‐β‐CD copolymers for cholesterol binding was evaluated using the lipid sequestration assay. The lipid sequestration assay indirectly measures the remaining cholesterol in solution using HPLC after mixing an emulsion of cholesterol and bile acids in fed‐state‐simulated intestinal fluid with PEI‐β‐CD for 10 h …”

Section: Sequestration In the Gastrointestinal Tractmentioning

confidence: 99%

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Polymer sequestrants for biological and environmental applications

Archer

Hall

Thompson

et al. 2019

Polymer International

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Toxic contaminates have profound consequences on both health and the environment. Consequently, effective approaches for addressing the effects of these toxicants are paramount. Here, we review recent progress in developing polymeric sequestrants for biological toxins, heavy metals and organic micropollutants. Polymers have several advantages as sequestration materials, including relatively low cost and high affinity for target compounds. As a result a number of polymer-based toxin-mitigation applications have been investigated. Naturally occurring toxins may be neutralized with polymers capable of binding and eliminating them from the body. Heavy metal contamination from mining operations, energy and industrial sources may also be mitigated with appropriate chelating polymers, both for environmental remediation and in chelation therapy for metal poisoning. Micropollutants such as pesticides from agriculture and polycyclic aromatic hydrocarbons from combustion processes may also be isolated using polymeric materials. Each of these applications illustrates the capabilities of polymers for eliminating toxic contaminants, thereby facilitating greater health and sustainability.

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Section: Sequestration In the Gastrointestinal Tractmentioning

confidence: 99%

Section: Sequestration In the Gastrointestinal Tractmentioning

confidence: 99%

Polymer sequestrants for biological and environmental applications

Archer

Hall

Thompson

et al. 2019

Polymer International

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“…Bile acids, another important physiological substance that is closely related to lipid metabolism, are the end products of cholesterol catabolism in the liver and secreted into the small intestine, which might activate PL and form micelles containing dietary fat and lipophilic vitamins (A, D, E, and K), thus facilitating fat absorption, distribution, metabolism, and excretion ( 108 – 110 ). Studies have shown that TCMPOs could bind with BAs ( Figure 2 ; Table 3 ) and destroy the mixed micelles formed by BAs with dietary lipids, thus preventing the digestion and absorption of dietary lipids.…”

Section: Antiobesity Mechanism Of Tcmposmentioning

confidence: 99%

Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

Zhi,

Chang,

Wang

et al. 2024

Front. Nutr.

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Traditional Chinese medicine (TCM) has displayed preventive and therapeutic effects on many complex diseases. As natural biological macromolecules, TCM-derived antiobesogenic polysaccharides (TCMPOs) exhibit notable weight-loss effects and are seen to be a viable tactic in the fight against obesity. Current studies demonstrate that the antiobesity activity of TCMPOs is closely related to their structural characteristics, which could be affected by the extraction and purification methods. Therefore, the extraction, purification and structural-property correlations of TCMPOs were discussed. Investigation of the antiobesity mechanism of TCMPOs is also essential for their improved application. Herein, the possible antiobesity mechanisms of TCMPOs are systematically summarized: (1) modulation of appetite and satiety effects, (2) suppression of fat absorption and synthesis, (3) alteration of the gut microbiota and their metabolites, and (4) protection of intestinal barriers. This collated information could provide some insights and offer a new therapeutic approach for the management and prevention of obesity.

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“…Obesity happens when energy expended is lower than that consumed. Therefore, it is an effective approach to fight against obesity by controlling the absorption of the energy-dense components in food, especially dietary fat [46]. Dietary fat mainly consists of mixed triglycerides [7].…”

Section: Anti-obesity Effect Via Inhibiting Fat Absorptionmentioning

confidence: 99%

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

Zhang

Xie

You

et al. 2021

eFood

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Nowadays, obesity in humans is a huge challenge requiring effective, readily available, and low-risk alternative treatments. Intake of edible Non-Digestible Polysaccharides (NDPs) is regarded as a promising strategy to combat obesity. Herein, an overview of the behavior of NDPs in the Gastrointestinal (GI) tract and its association with anti-obesity effect is summarized. Both the in vitro and in vivo of such investigations are discussed. Results show that NDPs can reach the large intestine to mediate the gut microbiota with the extent of regulation varies among NDPs with different chemical structures. The possible anti-obesity mechanisms associated with behavior of NDPs in the GI tract include: (i) inhibition of fat absorption, (ii) modification of gut microbiota and their metabolites such as short-chain fatty acids, (iii) regulation of bile acid profiles, (iv) modulation on appetite and satiety effect, and (v) protection of intestinal barrier. However, more efforts are required to clarify the exact behavior and their beneficial effects of NDPs within GI tract. This paper will provide an overlook of recent advances for better understanding anti-obesity activity of NDPs.

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Nonabsorbable polysaccharide-functionalized polyethylenimine for inhibiting lipid absorption

Cited by 7 publications

References 35 publications

Polymer sequestrants for biological and environmental applications

Polymer sequestrants for biological and environmental applications

Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

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