Nonalcoholic Fatty Liver Disease and the Kidney: A Review

Umbro, I.; Baratta, Francesco; Angelico, Francesco; Ben, Maria Del

doi:10.3390/biomedicines9101370

Cited by 12 publications

(7 citation statements)

References 56 publications

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“…NAFLD, one of the most common liver diseases, is a strong risk factor for chronic kidney disease (CKD) [ 41 , 42 ]. Liver-related portal inflammation [ 43 ] and portal hypertension can trigger a subclinical hepatorenal reflex, which over time may contribute to the development and progression of CKD [ 44 ]. Further mechanistic studies are needed in this area to better understand the interrelationship between liver regeneration, eGFR, CYP1A2 activity, and liver damage.…”

Section: Discussionmentioning

confidence: 99%

Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity

Ito,

Lemus,

2023

Diagnostics

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The liver plays an important role in normal metabolism and physiological functions such as acid-base balance; however, limited epidemiologic studies have investigated how the liver contributes toward acid-base balance using non-invasive biomarkers. We determined associations between serum biomarkers related to acid-base balance and renal function with liver CYP1A2 activity. We used data from 1381 participants of the 2009–2010 National Health and Nutrition Examination Survey (NHANES) with measurements of serum phosphorus, serum bicarbonate, caffeine intake, caffeine metabolites, and estimated glomerular filtration rate (eGFR). Liver CYP1A2 activity was estimated using urine caffeine metabolite indices, which were calculated as the ratio of one of the urine caffeine metabolites (i.e., paraxanthine and 1-methyluric acid) to caffeine intake. We analyzed associations in the whole data set and in different strata of hepatic steatosis index (HSI) based on different cut-points. We found that serum bicarbonate was positively associated with CYP1A2 activity in the whole data set when comparing persons with bicarbonate at Q4 to Q1 (β = 0.18, p = 0.10 for paraxanthine; β = 0.20, p = 0.02 for 1-methyluric acid). Furthermore, serum phosphorus was positively associated with CYP1A2 activity only in the stratum of 30 ≤ HSI < 36. Lastly, low eGFR was significantly associated with lower CYP1A2 activity measured with paraxanthine in the whole dataset and in all the strata with HSI < 42; when comparing eGFR < 60 to eGFR > 90, β estimates ranged from −0.41 to −1.38, p-values ranged from 0.0018 to 0.004. We observed an opposite trend in the highest stratum (HSI ≥ 42). Non-invasive measurements of serum bicarbonate, serum phosphorus, and eGFR have dynamic associations with CYP1A2 activity. These associations depend on the extent of liver damage and the caffeine metabolite used to assess CYP1A2 activity.

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Section: Discussionmentioning

confidence: 99%

Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity

Ito,

Lemus,

2023

Diagnostics

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“…Previous studies have demonstrated that fatty liver disease was strongly associated with the high risk of developing chronic kidney disease (CKD). 2,3 However, the proportion of patients concurrent with fatty liver disease was not provided in the study, and further subgroup analysis in patients with and without fatty liver disease would provide more information about the association between NUCs and CKD.…”

Section: Editorsmentioning

confidence: 99%

Letter: Impact of antiviral treatment on renal function in patients with chronic hepatitis B

Wang,

Fan,

Zhang

et al. 2024

Aliment Pharmacol Ther

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“…Inflammation and oxidative stress are suggested to be the key factors involved in the inflammatory mechanisms and pathways linking NAFLD to CKD and responsible for both the pathogenesis and the progression of CKD in patients with NAFLD. 7 It could also be attributed to co-existing co-morbidities, for instance, uncontrolled DM which can in itself lead to glomerulosclerosis and the development of diabetic nephropathy. Other risk factors might include the presence of obesity and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association of Low GFR and Non-Alcoholic Hepatosteatosis on Fibroscan of Liver

Baqai¹,

Mahmud²,

Anwar

et al. 2023

J Ayub Med Coll Abbottabad

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Background: Chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD) are becoming a health concern, owing to their increasing incidence and prevalence. Both entities are linked to poor outcomes and increased costs, hence greatly impacting the healthcare system and economy. Therefore, it is imperative to establish the link between the two, so as to prevent disease progression and complications. Methods: The study was an observational retrospective study done in Karachi, from November 2021 to May 2022. It was conducted on 255 patients who were diagnosed with NAFLD, and the presence of CKD was then determined by calculating their GFRs. Results: Out of the 255 patients diagnosed with hepatosteatosis, 76% had a normal GFR, 20% had a mild decrease and 4% were noted to have a moderate reduction in their GFR. When cross-tabulated with CAP score, it was found that 28% had S1 grade steatosis, out of which 85% had a normal GFR, 13% had a mild decrease and 2% had a moderate decrease in GFR. 22% had S2 grade steatosis, out of which 76% had a normal GFR, 18% had a mild decrease and 6% had a moderate reduction in GFR. 50% patients had S3 grade steatosis, out of which 70% had a normal GFR, 25% had a mild decrease and 5% had a moderate reduction in GFR. Conclusion: There is an association present between NAFLD and the development of low GFR. Therefore, it is important that patients diagnosed with NAFLD are regularly screened for CKD, so as to prevent its development and complications.

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Nonalcoholic Fatty Liver Disease and the Kidney: A Review

Cited by 12 publications

References 56 publications

Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity

Serum Phosphorus, Serum Bicarbonate, and Renal Function in Relation to Liver CYP1A2 Activity

Letter: Impact of antiviral treatment on renal function in patients with chronic hepatitis B

Association of Low GFR and Non-Alcoholic Hepatosteatosis on Fibroscan of Liver

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