Nonalcoholic fatty liver disease in lean subjects: is it all metabolic-associated fatty liver disease?

Machado, Mariana Verdelho

doi:10.20517/2394-5079.2020.90

Cited by 6 publications

(6 citation statements)

References 160 publications

(251 reference statements)

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“…With numerous factors that can lead to NAFLD, high visceral fat, also known as visceral adipose tissue (VAT), is one of the prominent observations present in a subset of NAFLD patients [10]. It is also well established that beyond a certain threshold, excess VAT may result in a malfunction of adipose tissue and cardiometabolic disturbances [11]. As such, VAT is a measurement of concern that can be studied for its relationship with NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

Seaw,

Henry,

2023

Livers

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Imaging-based body composition analysis can quantify visceral fat, which is an important feature of lean non-alcoholic fatty liver disease (NAFLD) patients. This review assesses current evidence of the relationship between NAFLD, particularly hepatic steatosis, and visceral fat that is measured using imaging-based body composition analysis. PubMed Central and ScienceDirect were searched for studies that provided quantification of the relationship between NAFLD, hepatic steatosis and visceral fat. Twenty studies comprising 15,763 subjects were included, consisting of the relationship with NAFLD (n = 15) and the relationship with hepatic steatosis (n = 7). All studies reported a positive relationship between NAFLD and visceral fat. For hepatic steatosis regardless of severity, only one study reported no correlation with visceral fat. Further results showed that visceral fat is more related to NAFLD and hepatic steatosis in females than males. More studies including NAFLD of different stages must be performed in the future to validate the degree of association between visceral fat and NAFLD at all stages as well as this relationship difference between genders.

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Section: Introductionmentioning

confidence: 99%

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

Seaw,

Henry,

2023

Livers

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“…MASLD is the hepatic expression of adiposopathy, which occurs when the adipose tissue capacity is surpassed by surplus energy ( 6 ). Severe obesity systematically exceeds the adipose tissue capacity ( 13 ), but each individual has its own intrinsic threshold, which may be surpassed even in the range of normal body weight index (BMI) ( 14 , 15 ). Adiposopathy promotes MASLD but also metabolic dysfunction, cardiovascular disease, and cancer.…”

Section: Management Of Adiposopathymentioning

confidence: 99%

MASLD treatment—a shift in the paradigm is imminent

Machado

2023

Front. Med.

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MASLD prevalence is growing towards the leading cause of end-stage liver disease. Up to today, the most effective treatment is weight loss. Weight loss interventions are moving from lifestyle changes to bariatric surgery or endoscopy, and, more recently, to a new wave of anti-obesity drugs that can compete with bariatric surgery. Liver-targeted therapy is a necessity for those patients who already present liver fibrosis. The field is moving fast, and in the near future, we will testify to a disruptive change in MASLD treatment, similar to the paradigm-shift that occurred for hepatitis C almost one decade ago with direct antiviral agents.

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“…78 Lastly, exercise modulates myokines production. 7 Exercise induces the release of irisin that promotes beijing of white adipose tissue, increasing energy expenditure. 68 Irisin also has direct anti-steatogenic effects on the liver, through activation of PPAR-γ and upregulation of fibroblast growth factor (FGF)-21.…”

Section: Physiopathology Of Exercise and Mafldmentioning

confidence: 99%

“…An overwhelmed adipose tissue can also arise in subjects with normal body mass index, in which the personal fat threshold, that is the amount of fat the individual adipose tissue can handle, is surpassed. 7 The sick adipose tissue releases fat that accumulates ectopically in the liver, but also in the cardiovascular system, and promotes systemic inflammation, insulin resistance, and the metabolic syndrome. The fatty liver further enhances insulin resistance and derangements in lipid metabolism, ensuing in a loop of metabolic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise in the Management of Metabolic Dysfunction Associated Fatty Liver Disease

Machado¹

2021

DMSO

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Sedentarism is the pandemic of modern times. It is associated with several medical conditions including obesity, type 2 diabetes mellitus, cardiovascular diseases and also liver disease, particularly metabolic dysfunction associated fatty liver disease (MAFLD). In an era when MAFLD is the most prevalent chronic liver disease worldwide, whilst no pharmacological therapy has been approved for it, exercise has proved to be effective in improving liver steatosis. Interestingly, exercise decreases liver fat even in the absence of weight loss. The challenge for the clinician is to motivate the obese patient with MAFLD, and associated co-morbidities, who has crystallized a sedentary behavior, at times when every need is at the distance of a click on the Internet, and the entire world can be visited behind a screen. In this review, the aggregate evidence on the mechanisms and effects of exercise in the management of MAFLD is summarized, with simple recommendations for everyday clinical practice.

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Nonalcoholic fatty liver disease in lean subjects: is it all metabolic-associated fatty liver disease?

Cited by 6 publications

References 160 publications

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

Relationship between Non-Alcoholic Fatty Liver Disease and Visceral Fat Measured by Imaging-Based Body Composition Analysis: A Systematic Review

MASLD treatment—a shift in the paradigm is imminent

Aerobic Exercise in the Management of Metabolic Dysfunction Associated Fatty Liver Disease

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