Nonalcoholic Steatohepatitis: The Second Leading Indication for Liver Transplantation in the USA

Chedid, Marcio

doi:10.1007/s10620-017-4724-6

Cited by 27 publications

(20 citation statements)

References 10 publications

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“…Prevalence has been observed to be higher in patients with metabolic abnormalities, such as obesity and diabetes mellitus . NAFLD is currently the second leading indication for liver transplantation in the United States and is foreseen to become the leading indication if the prevalence of NAFLD increases significantly, as predicted, over the next 10 years . Additionally, NAFLD represents a significant clinical burden due to its association with metabolic syndrome, renal disease, and increased overall and cardiovascular‐related mortality .…”

mentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease and Renal Function Impairment: A Cross‐Sectional Population‐Based Study on Its Relationship From 1999 to 2016

Yeo

Henry

et al. 2019

Hepatol Commun

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There is growing evidence that links nonalcoholic fatty liver disease (NAFLD) with impairment of renal function. As such, we aimed to demonstrate the trend of NAFLD, NAFLD with renal insufficiency (RI), disease awareness, and mortality over time. Patient data were extracted from the National Health and Nutrition Examination Survey (NHANES) 1999‐2016. A total of 14,255 adult study participants without competing liver disease or heavy drinking and with complete laboratory data were included. NAFLD was defined using the U.S. Fatty Liver Index (USFLI) and RI was defined using the Chronic Kidney Disease Epidemiology Collaboration equation and urine albumin:creatinine ratio. Death data were obtained from the National Death Index (up to December 31, 2015). Prevalence of NAFLD in participants was 31.2% (95% confidence interval [CI], 30.01‐32.46); of these participants, 22.05% (95% CI, 20.34‐23.85) had RI. From 1999 to 2016, prevalence of both NAFLD without RI (P = 0.048) and NAFLD‐RI (P = 0.006) increased significantly. Among those with NAFLD‐RI, awareness of kidney disease was 8.56% (95% CI, 6.69‐10.89), while awareness of liver disease among all NAFLD was 4.49% (95% CI, 3.17‐6.33). Among those with NAFLD, mortality incidence per 1,000 person years was highest among those with severe RI in all‐cause mortality (104.4; 95% CI, 83.65‐130.39) and other residual causes of mortality (mean, 50.88; 95% CI, 37.02‐69.93). Conclusion: Prevalence of NAFLD and NAFLD‐RI has increased over the past 2 decades in the United States. Low kidney disease and liver disease awareness are major public health issues as those with NAFLD‐RI have significantly higher mortality than those with only NAFLD.

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confidence: 99%

Nonalcoholic Fatty Liver Disease and Renal Function Impairment: A Cross‐Sectional Population‐Based Study on Its Relationship From 1999 to 2016

Yeo

Henry

et al. 2019

Hepatol Commun

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“…Obesity and in ammation exist in the same time in FL almost, successive stages in FL may be re ected by the accumulation of fat in hepatocytes and the onset of steatohepatitis. Although the etiology of FL is multifactorial, it is well accepted that in ammation is a central component of FL pathogenesis [36,37]. This may explain why the AST/ALT has the maximum increase in our study.…”

Section: Discussionmentioning

confidence: 58%

The Comparation of Anthropometric and Metabolic Indices in the Regulation and Prediction of Fatty Liver: a population-based cross-sectional study in China

Xie

Pei

Wang

et al. 2020

Preprint

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Background: The association between anthropometric and metabolic indices and fatty liver (FL) remain not fully elucidated. We aimed to determine the role of these anthropometric and metabolic indices on FL prediction and regulation via cross-sectional study, thus providing clues for further research in FL field. Methods: A total of 658 participants aged over 18 years were included in this study. Anthropometric and metabolic indices (including WC, WHR, BMI, BFM, VFA, TG/HDL, AST/ALT, SBP, DBP and FBG) were measured. Difference analyses, logistic and predictive analyses were used to evaluate the association and discrimination ability between these indices and FL. Results: Compared with non-FL, anthropometric and metabolic indices in FL and mild FL people showed a significant increase after adjustment. In the multivariate ranked logistic regression analysis, WC, TG/HDL, AST/ALT and FBG have a strong association with FL (β = 0.03, 0.19, 0.41, -1.89 and 0.28, P<0.05). And AST/ALT showed the lowest predicted power with an AUC of 0.22 among all indices. WC showed to be the best predictors with an AUC of 0.86 in participants.Conclusions: This is a comprehensive profile for FL related indices. These can enhance our understanding of the mechanisms for hepatic on inflammation and fat and is also important for the prevention and treatment of FL.

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“…It has been reported that approximately 20-30% of subjects with HS would develop NASH [5]. Moreover, NASH has become the leading cause of liver failure and the major indication for liver transplantation [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

et al. 2020

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Background: Non-alcoholic fatty liver disease (NAFLD) is currently the major cause of chronic liver disease globally. Bile acids (BAs) have emerged as relevant signaling molecules that are associated with NAFLD development. This study was aimed to examine the association of serum total bile acids (TBAs) with NAFLD in a large population of Chinese subjects. Methods: This cross sectional study recruited 152,336 participants from the Second Xiangya Hospital, China. NAFLD was diagnosed based on the presence of hepatic steatosis on ultrasonography, without significant alcohol consumption and other known causes for chronic liver disease. A multivariate logistic regression model was used to test for the association of serum TBAs with NAFLD, adjusting for conventional risk factors of NAFLD. Results: A total of 27.4% of the participants had NAFLD. Patients with NAFLD had slightly higher TBA levels than those without, 3.4 vs. 3.0 μmol/L (p < 0.001). However, TBA levels were not associated with NAFLD in the multivariate logistic regression model, which adjusted for age, gender and other acknowledged risk factors for NAFLD (OR = 1.00. 95% CI: 1.00-1.00, p = 0.797). Conclusions: We found that the serum TBA levels were not associated with NAFLD. Future studies in a large population, focusing on serum BA composition may improve the understating of the role of BAs in NAFLD.

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Nonalcoholic Steatohepatitis: The Second Leading Indication for Liver Transplantation in the USA

Cited by 27 publications

References 10 publications

Nonalcoholic Fatty Liver Disease and Renal Function Impairment: A Cross‐Sectional Population‐Based Study on Its Relationship From 1999 to 2016

Nonalcoholic Fatty Liver Disease and Renal Function Impairment: A Cross‐Sectional Population‐Based Study on Its Relationship From 1999 to 2016

The Comparation of Anthropometric and Metabolic Indices in the Regulation and Prediction of Fatty Liver: a population-based cross-sectional study in China

The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

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