Nonbacterial thrombotic endocarditis: A review

Lopez, J.Antonio; Ross, Robert S.; Fishbein, Michael C.; Siegel, Robert J.

doi:10.1016/0002-8703(87)90719-8

Cited by 363 publications

(290 citation statements)

References 74 publications

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“…There is a wellrecognized association between NBTE and various malignancies and autoimmune disorders. 15 Typically, the underlying malignancy is a solid tumor with adenocarcinomas being the most common. 16 However, none of the endocarditis patients in our cohort had an autoimmune disorder, and only one patient underwent HSCT for a solid tumour (ovarian carcinoma).…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcome of patients developing endocarditis following hematopoietic stem cell transplantation

Kuruvilla

Forrest

Lavoie

et al. 2004

Bone Marrow Transplant

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Section: Discussionmentioning

confidence: 99%

Characteristics and outcome of patients developing endocarditis following hematopoietic stem cell transplantation

Kuruvilla

Forrest

Lavoie

et al. 2004

Bone Marrow Transplant

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“…No sex predilection has been reported. The incidence of systemic emboli varies widely (14%-91%, with an average of 42%) [22].…”

Section: Incidence and Clinical Featuresmentioning

confidence: 99%

“…In the authors' anecdotal experience with patients suffering from Trousseau's syndrome, occasional patients who have failed low molecular weight heparin therapy have been successfully managed with unfractionated heparin. In contrast to heparins, vitamin K antagonists such as warfarin should not be used in patients with malignancy-associated NBTE, as recurrent thromboembolic events while on warfarin are common [22,38,39]. Although the exact reason for warfarin's inability to control the coagulopathy associated with NBTE is not precisely known, the presence of non-vitamin K dependent agents that induce the thrombotic coagulopathy has been suggested by some investigators [40].…”

Section: Managementmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment

2007

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LEARNING OBJECTIVES1. Enumerate procoagulant factors present in malignancy and the risk for thromboembolic events.2. Describe the morbidity associated with nonbacterial thrombotic endocarditis.3. List the recommended evaluations and treatments for nonbacterial thrombotic endocarditis.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME ABSTRACTThrombophilia is a well-described consequence of cancer and its treatment. The pathogenesis of this phenomenon is complex and multifactorial. Nonbacterial thrombotic endocarditis (NBTE) is a serious and potentially underdiagnosed manifestation of this prothrombotic state that can cause substantial morbidity in affected patients, most notably recurrent or multiple ischemic cerebrovascular strokes. Diagnosis of NBTE requires a high degree of clinical suspicion as well as the judicious use of two-dimensional echocardiography to document the presence of valvular thrombi. In the absence of contraindications to therapy, treatment consists of systemic anticoagulation, which may ameliorate symptoms and prevent further thromboembolic episodes, as well as control of the underlying malignancy whenever possible. The Oncologist 2007;12:518 -523 Disclosure of potential conflicts of interest is found at the end of this article.

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“…Involvement of the right-sided heart valves has also been reported. Vegetations typically occur at the coapting edge of the leaflets and in general do not alter or impede valve function 27 (Figure 4). The masses vary in size from microscopic to large and exuberant, with a tendency to detach and cause embolism.…”

Section: Marantic Endocarditis Associated With Cancermentioning

confidence: 99%

Cardiac Valve Involvement in Systemic Diseases: A Review

Grimaldi

Vermi

Pappalardo

et al. 2013

Clinical Cardiology

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Increasing age and new trends of mixed populations have newly aroused interest in valvular heart disease in the developed countries still in need of new clinical insights. In the clinical setting of systemic diseases, the proper assessment of cardiovascular abnormalities may be challenging, and the characterization of valvular involvement might help to recognize the underlying disease and cardiac sequelae. Prompt identification of valvular lesions may, therefore, also be useful for differential diagnosis. This article reviews the cardiac involvement in systemic diseases from etiology and background definition to echocardiographic assessment and clinical interpretation.The authors have no funding, financial relationships, or conflicts of interest to disclose.

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Nonbacterial thrombotic endocarditis: A review

Cited by 363 publications

References 74 publications

Characteristics and outcome of patients developing endocarditis following hematopoietic stem cell transplantation

Characteristics and outcome of patients developing endocarditis following hematopoietic stem cell transplantation

Nonbacterial Thrombotic Endocarditis in Cancer Patients: Pathogenesis, Diagnosis, and Treatment

Cardiac Valve Involvement in Systemic Diseases: A Review

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