Noncasein Protein to Casein Ratio of Feeding Formulas&lt;subtitle&gt;Effect on Blood Component Levels in Normal Infants&lt;/subtitle&gt;

Natelson, Samuel; Penniall, Ralph; Crawford, Woodruff L.; Munsey, Franklin A.

doi:10.1001/archpedi.1955.02050110796002

Cited by 4 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar trends were found in infant studies (19,24), but Jarvenpaa et ul. ( 17) found no differences between casein and whey proteins.…”

Section: Discussionsupporting

confidence: 85%

“…In term infants, plasma urea concentration was also reduced by a formula containing predominantly whey proteins (19), but a recent study detected no differences in the utilization of casein and whey proteins (17). As it was desired to test the validity of the neonatal pig as a model for infant nutrition, milks containing either casein or whey as the predominant protein have been compared at two levels of protein intake in neonatal pigs.…”

Section: Dm Dry Mattermentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Neonatal Pig As a Model for Infant Nutrition: Effects of Different Proportions of Casein and Whey Protein in Milk on Nitrogen Metabolism and Composition of Digesta in the Stomach

Newport¹,

Henschel²

1984

Pediatr Res

View full text Add to dashboard Cite

Summarygiven formulas containing predominantly whey proteins did Abbreviation DM, dry matterSimilarities in the digestive system of man and the pig suggest that results of studies on digestion and nutrition in the pig may be applicable to man (9). Some similarities in neonatal glucose metabolism have also been demonstrated (1 3). Other studies in neonatal pigs have assumed that results may be relevant, for example, in studies on protein nutrition (28, 23). However, no systematic comparisons of protein utilization have been made between the two species during the neonatal period. Such comparisons must inherently be rather superficial since ethical considerations limit the data on protein nutrition and digestion from infants to parameters of growth, nutrient retention, and analyses of blood.Between species, there is considerable variation in the proportions of casein and whey proteins in the protein of the milk. Whey proteins account for about 20, 50, and 80% of the total protein in bovine (26), porcine (27), and human milks (16), respectively. The desire to "humanize" dried milk formulas for infants which were previously based on unmodified bovine milk gave rise to studies in which formulas containing predominantly casein or whey protein were compared in infants. At the time of these studies, it was believed that whey proteins contributed only 60% of the total protein in human milk (16). Although not all differences were statistically significant, low birth weight infants show improved N retention (2) and reduced concentrations of urea in plasma (24), suggesting a better utilization of the protein.Increasing the protein concentrations in the milk also reduced the efficiency of protein utilization (24). In term infants, plasma urea concentration was also reduced by a formula containing predominantly whey proteins (19), but a recent study detected no differences in the utilization of casein and whey proteins (17). As it was desired to test the validity of the neonatal pig as a model for infant nutrition, milks containing either casein or whey as the predominant protein have been compared at two levels of protein intake in neonatal pigs. In view ofthe substantial proportion of whey proteins in sow's milk, enriching a milk substitute with whey proteins could also have important implications in the rearing of early weaned pigs.These studies have also been extended to compare gastric digestion and emptying following slaughter under standardized conditions. I n vifro studies in our laboratory (unpublished) showed that the coagulation time following the addition of bovine chymosin was inversely related to the casein content of the milks. Therefore, an increase in the proportion of whey protein might increase the rate of gastric emptying. Previous work has shown that whole cow's milk quickly coagulated in the stomach of the 4-week-old pig, followed by rapid draining of the whey (6). Also, the amount of dry matter in the stomach was usually decreased when milk was replaced by noncoagulating proteins derived from soybea...

show abstract

“…Similar trends were found in infant studies (19,24), but Jarvenpaa et ul. ( 17) found no differences between casein and whey proteins.…”

Section: Discussionsupporting

confidence: 85%

Section: Dm Dry Mattermentioning

confidence: 99%

Evaluation of the Neonatal Pig As a Model for Infant Nutrition: Effects of Different Proportions of Casein and Whey Protein in Milk on Nitrogen Metabolism and Composition of Digesta in the Stomach

Newport¹,

Henschel²

1984

Pediatr Res

View full text Add to dashboard Cite

show abstract

“…Such comparisons are complicated by differences in intakes, sampling times of plasma, and postnatal ages. Possibly the closest comparison may be made to values reported for infants fed pooled human milk every 1 to 2 h and in whom plasma values were obtained randomly (5,9,10,16,19). Again, threonine and valine levels in plasma of infants who were fed fortified human milk fell slightly below 1 SD of the mean value measured in the comparison group.…”

mentioning

confidence: 95%

Plasma Amino Acid Differences in Very Low Birth Weight Infants Fed either Human Milk or Whey-Dominant Cow Milk Formula

Schanler

Garza

1987

Pediatr Res

View full text Add to dashboard Cite

When VLBW infants are fed a cow milk-based formula, a whey-rather than a casein-dominant formulation is recommended often (1,2). The assumption implicit in this recommendation is that an increased proportion of bovine milk whey in the formula's protein substantially increases the similarity between the formula and human milk (2). Differences in the proteins found in human and bovine wheys, however, weaken this premise. The predominant proteins in human whey are alactalbumin, SIgA, and lactoferrin; those predominant in bovine whey are p-lactoglobulin, IgG, and a-lactalbumin. The amino

show abstract

Fluid and Electrolyte Applications

Natelson

1975

Principles of Applied Clinical Chemistry Chemical Background and Medical Applications

View full text Add to dashboard Cite

Noncasein Protein to Casein Ratio of Feeding Formulas<subtitle>Effect on Blood Component Levels in Normal Infants</subtitle>

Cited by 4 publications

References 15 publications

Evaluation of the Neonatal Pig As a Model for Infant Nutrition: Effects of Different Proportions of Casein and Whey Protein in Milk on Nitrogen Metabolism and Composition of Digesta in the Stomach

Evaluation of the Neonatal Pig As a Model for Infant Nutrition: Effects of Different Proportions of Casein and Whey Protein in Milk on Nitrogen Metabolism and Composition of Digesta in the Stomach

Plasma Amino Acid Differences in Very Low Birth Weight Infants Fed either Human Milk or Whey-Dominant Cow Milk Formula

Fluid and Electrolyte Applications

Contact Info

Product

Resources

About