Nonclassical Roles for IFN-γ and IL-10 in a Murine Model of Immunoedition

Abstract

Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response.

Interleukin‑18 and ‑10 may be associated with lymph node metastasis in breast cancer

“…IL-10 is a protein with a molecular weight of 35–40 kDa that was discovered by Fiorentino in 1989 ( 30 ). IL-10 is a multifunctional negative regulator that is primarily secreted by monocytes, helper T lymphocytes (Th2), macrophages and activated B cells; it exerts an immunosuppressive function during malignancy development, which effectively reduces the participation of tumor-immune cytokines, thereby inducing immune escape and promoting tumor growth ( 31 ). In the present study, IL-10 was positively expressed in the majority of the breast cancer tissues, but expressed at low levels in the breast fibroadenoma tissues.…”