Noncovalent structural locking of thermoresponsive polyion complex micelles, nanowires, and vesicles via polymerization-induced electrostatic self-assembly using an arginine-like monomer

Abstract

The noncovalent locking of nanostructured thermoresponsive polyion complexes can be achieved via polymerization-induced electrostatic self-assembly (PIESA) using an arginine-like cationic monomer.

Principles and Characteristics of Polymerization-Induced Self-Assembly with Various Polymerization Techniques

“…The thermal behavior of nanoparticles prepared with an inherently different aqueous PISA protocol was reported recently by Cai and co-workers in 2020. 45 In contrast to the previously discussed formulations, this aqueous PISA formulation is based on the chain extension of a macromolecular chain transfer agent (macro-CTA), poly[N-(2-hydroxypropyl)methacrylamide], with a charged core-forming monomer in the presence of an oppositely charged homopolymer. The resulting nanoparticles are polyion complexes.…”

“…Repeat units of opposite charge can also be introduced as (or within) a third block, leading to spheres, worms, vesicles, and lamella. 45,163,164 Moreover, it is worth mentioning that Cai and co-workers 165 recently established a well-considered seeded RAFT-PIESA protocol that allowed the preparation of multicompartmentalized micelles, nanosheets, and nanocages. This work is based on the synthesis of a positively charged diblock copolymer in the presence of an oppositely charged nonreactive diblock copolymer sphere.…”

Solvent‐Controlled Topological Evolution from Nanospheres to Superhelices

“…These observations indicated that the aromatic interactions among benzene core were weakened and the indole side chain participated in stronger π-π stacking. [47] Taken together, it could be concluded that higher H 2 O contents could lead to stronger hydrogen bonding and induced π-π interactions among LPWM molecules. Note that the decrease in the integral of the signals upon increasing the D 2 O content was likely caused by its migration from the liquid phase into an aggregative phase, the existence of buried monomers inside the nanostructures was considered not accessible to the solvent.…”

Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly

“…More recently, Zhao et al prepared thermoresponsive polyion complex (PIC) nanostructures through polymerization-induced electrostatic self-assembly (PIESA) of a cationic arginine-like core-forming monomer, namely, N -(2-guanidinoethyl)methacrylamide (GEMA), and simultaneous non-covalent structural locking with anionic poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) by H-bonding [ 105 ]. Visible light-initiated RAFT polymerization of GEMA was performed in an acidic aqueous solution of PAMPS at 25 °C using a hydrophilic poly( N -2-hydroxypropylmethacrylamide) (PHPMAm) macro-CTA as the corona-forming block.…”

“…More recently, Zhao et al prepared thermoresponsive polyion complex (PIC nanostructures through polymerization-induced electrostatic self-assembly (PIESA) of cationic arginine-like core-forming monomer, namely, N-(2-guanidinoethyl)methacryla mide (GEMA), and simultaneous non-covalent structural locking with anionic poly(2 More recently, Zhao et al prepared thermoresponsive polyion complex (PIC) nanostructures through polymerization-induced electrostatic self-assembly (PIESA) of a cationic arginine-like core-forming monomer, namely, N-(2-guanidinoethyl)methacrylamide (GEMA), and simultaneous non-covalent structural locking with anionic poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) by H-bonding [105]. Visible light-initiated RAFT polymerization of GEMA was performed in an acidic aqueous solution of PAMPS at 25 • C using a hydrophilic poly(N-2-hydroxypropylmethacrylamide) (PHPMAm) macro-CTA as the corona-forming block.…”