Nonfatal Chromobacterial Sepsis

Chromobacterium violaceum infection: A clinical review of an important but neglected infection

“…23,26 One patient had an infection relapse because of the inadequate duration of treatment. 4 Two patients experienced reinfection in two different episodes: one had two episodes of infection, separated by 3 years after exposure to the same source, 24 while another was infected a second time 2 years after the first episode. 22 4.…”

Ecthyma gangrenosum and septic shock syndrome secondary to Chromobacterium violaceum

“…19 C violaceum infection typically begins with exposure of broken skin to contaminated water or soil, followed by cellulitis and, often, the development of lymphadenitis, cutaneous lesions, and visceral abscesses 22 (most commonly of the liver, kidney, and lungs). 10,23,24 Other clinical presentations have included urinary tract infection, 12 gastroenteritis, 12 osteomyelitis, 25 meningitis, 26,27 diarrhea, 28,29 sinusitis, and orbital cellulitis. [30][31][32] Reported time between exposure and presentation of symptoms has ranged from 1 day to 2 months.…”

“…20,38 Unfortunately, even aggressive therapy may not stop the progression to death, 6 as evidenced by the high rates of mortality associated with C violaceum infections. 5,10,13,39 Among patients who survive, recurrence of infection is not uncommon and has occurred after completion of therapy and apparent cure even in immunocompetent individuals. 5,15,38,40 This finding leads to suggestions that patients be screened with abdominal ultrasonography 15 or computed tomographic scan 38 for hidden septic foci that may remain after treatment and resolution of symptoms.…”

“…2 Septic shock may develop rapidly along with visceral abscesses often involving the liver, lung, and spleen. 10 Here we report an aggressive yet nonfatal case of C violaceum septicemia in an adolescent, resulting in a new diagnosis of chronic granulomatous disease (CGD).…”

Successful Treatment of an Infant with Chromobacterium violaceum Sepsis

“…They have shown similarities in both presentation and severity of illness [3,[6][7][8][9][10][11][12][13]. Mortality rates 160% have been reported [7,14]. The constellation of findings attributed to C. violaceum sepsis has most commonly included fever, hepatic abscesses, and skin lesions.…”