Nongastric Marginal-Zone B-Cell MALT Lymphoma: Prognostic Value of Disease Dissemination

Arcaini, Luca; Burcheri, Sara; Rossi, Andrea; Passamonti, Francesco; Paulli, Marco; Boveri, Emanuela; Brusamolino, Ercole; Orlandi, Ester; Molteni, Alfredo; Pulsoni, Alessandro; Cox, Maria Christina; Orsucci, Lorella; Fabbri, Alberto; Frezzato, Maurizio; Voso, Maria Teresa; Zaja, Francesco; Montanari, Francesca; Pascutto, Cristiana; Morra, Enrica; Cortelazzo, Sergio; Lazzarino, Mario

doi:10.1634/theoncologist.11-3-285

Cited by 66 publications

(58 citation statements)

References 18 publications

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“…The mediastinal adenopathy designation in our patients could confer behaviour closer to nodal MZLs rather than MALT lymphoma, in accordance with a previous report [31]. Although there are conflicting results regarding the influence of dissemination on survival [1,32], an extrapulmonary location was not associated with a shorter PFS or overall survival in this series. Indeed, the impact of extensive evaluation at diagnosis, including bone marrow biopsy and endoscopic examination of the gastrointestinal tract, should be better evaluated in patients who cannot be cured by local therapy.…”

Section: Discussionsupporting

confidence: 90%

Clinical characteristics and prognostic factors of pulmonary MALT lymphoma

Borie¹,

Wislez²,

Thabut³

et al. 2009

Eur Respir J

178

185

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Mucosa-associated lymphoid tissue-derived (MALT) lymphoma, a low grade B-cell extranodal lymphoma, is the most frequent subset of primary pulmonary lymphoma. Our objective was to evaluate the initial extent of disease and to analyse the characteristics and long-term outcome of these patients.All chest and pathological departments of teaching hospitals in Paris were contacted in order to identify patients with a histological diagnosis of primary pulmonary lymphoma of the MALT subtype.63 cases were identified. The median age was 60 yrs. 36% of cases had no symptoms at diagnosis. 46% of patients had at least one extrapulmonary location of lymphoma. The estimated 5-and 10-yr overall survival rates were 90% and 72%, respectively. Only two of the nine observed deaths were related to lymphoma. Age and performance status were the only two adverse prognostic factors for survival. Extrapulmonary location of lymphoma was not a prognostic factor for overall survival or for progression-free survival. Treatment with cyclophosphamide or anthracyclin was associated with shorter progression-free survival, when compared with chlorambucil.The survival data confirm the indolent nature of pulmonary MALT lymphoma. Better progression-free survival was observed with chlorambucil when compared with cyclophosphamide or anthracyclin.

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Section: Discussionsupporting

confidence: 90%

Clinical characteristics and prognostic factors of pulmonary MALT lymphoma

Borie¹,

Wislez²,

Thabut³

et al. 2009

Eur Respir J

178

185

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“…localized orbital, salivary gland and thyroid lymphoma, most frequently include radiotherapy as first-line therapy, whereas chemotherapy is administered for localized pulmonary lymphoma. 5 In case of multiorgan involvement, which can be expected in almost 50% of the patients, according to this study and others, 10,12,13 systemic therapy with either chemotherapy or chemotherapy in combination with rituximab could be a good treatment approach. Alkylating agents, fludarabine, cladribine and platinum compounds as single agents or in combination have been active with good response rates (i.e.…”

mentioning

confidence: 55%

Dissemination patterns in non-gastric MALT lymphoma

Boer¹,

Hiddink²,

Raderer³

et al. 2008

Haematologica

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“…Extranodal marginal zone B-cell lymphoma, a subtype of NHL, is the third most common form of NHL and it accounts for approximately 5% of NHL cases (4)(5)(6). It is histologically characterized by a heterogeneous cellular composition, including marginal zone or centrocytelike cells, monocytoid B cells, small lymphocytes, and plasma cells (7).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that MZL is associated with chronic antigenic stimulation, either by autoantigen or pathogen, leading to the accumulation of lymphoid tissue in the involved organs (8,9). While the gastrointestinal tract is the most common site, approximately 5% of extranodal MZL is found in the lung (5,6). Extranodal marginal zone B-cell lymphoma can affect any age group of either sex.…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Extranodal Marginal Zone Lymphoma: An Atypical Radiological Pattern

Kabalak¹,

Öz²,

Kankaya³

et al. 2017

Respir Case Rep

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Primary pulmonary extranodal marginal zone lymphoma (PPEMZL) arising from the mucosa-associated lymphoid tissue of the bronchus is a very rare disorder. It appears in the form of a slowly progressing localized mass or consolidation. Clinical presentation may include non-specific pulmonary symptoms, such as chronic cough, or dyspnea, but it is more often diagnosed incidentally. Computed tomography (CT) the thorax revealed that the present patient had a giant cystic lesion, parenchymal nodules, and consolidation area. The patient was symptomatic and diagnosed as marginal zone lymphoma by immunohistochemical study of the transthoracic biopsy specimen. This patient is thought to be the first diagnosed as PPEMZL from a cystic lesion.

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Nongastric Marginal-Zone B-Cell MALT Lymphoma: Prognostic Value of Disease Dissemination

Cited by 66 publications

References 18 publications

Clinical characteristics and prognostic factors of pulmonary MALT lymphoma

Clinical characteristics and prognostic factors of pulmonary MALT lymphoma

Dissemination patterns in non-gastric MALT lymphoma

Primary Pulmonary Extranodal Marginal Zone Lymphoma: An Atypical Radiological Pattern

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