Nonhematopoietic Gastrointestinal Neoplasia in Cats: A Retrospective Study of 44 Cases

Turk, Margaret A.; Gallina, A. M.; Russell, T. S.

doi:10.1177/030098588101800506

Cited by 66 publications

(65 citation statements)

References 8 publications

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“…In contrast, in humans, the majority of intestinal adenocarcinomas arise out of benign adenomatous polyps, 21 and in sheep, about 50% of reported cases had 1 or more polyps. 32,52 Similarly, the mucinous subtype of adenocarcinoma observed in one-third of the deer in the present study has not been reported in sheep or cattle 16,32 and is infrequently seen in cats (20%) 39,51 and humans (10%). 18 In the deer, there was far less infiltrative growth by this tumor subtype compared with the tubular subtype.…”

Section: Discussionsupporting

confidence: 59%

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

Toolan¹,

Jahns

2014

Vet Pathol

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Intestinal adenocarcinomas were identified in 76 adult deer from a closed herd of 193 breeding animals grazing pasture heavily infested with bracken fern (Pteridium aquilinum). Tumors were observed postmortem in 32 animals with rapid weight loss, and similar neoplasms were detected in a further 44 clinically normal deer at ''cull.'' Tumors were located in distal ileum, cecum, and proximal colon and presented as single (26%) or multiple (74%), variably sized, pale-gray, firm, poorly circumscribed neoplasms with associated intestinal strictures. Histopathologically tumors were well-differentiated, locally infiltrative, low-grade adenocarcinomas of tubular (51%), mucinous (33.5%), or mixed (15.5%) types. Extraintestinal metastases were not observed. The high incidence of intestinal adenocarcinoma within this herd suggests a specific and novel syndrome, and genetic and/or environmental factors may be involved in the pathogenesis.

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Section: Discussionsupporting

confidence: 59%

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

Toolan¹,

Jahns

2014

Vet Pathol

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“…Prior studies have suggested a higher intestinal carcinoma incidence in the Siamese breed (Kosovsky et al, 1988;Patnaik et al, 1976;Turk et al, 1981;Rissetto et al, 2011). While this study could not determine incidence, Siamese carcinoma cases (n=14) were analysed in terms of segmental distribution and histopathologic category where these were known (Table 1).…”

Section: Histopathologymentioning

confidence: 98%

Enterohepatic Helicobacter spp. in cats with non-haematopoietic intestinal carcinoma: a survey of 55 cases

Swennes

Parry

Feng

et al. 2016

Journal of Medical Microbiology

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Several enterohepatic Helicobacter spp. (EHS) have been isolated from cats. Despite the reported association between EHS infection and intestinal neoplasia in other species, this association has not been explored in cats. In this study, 55 non-haematopoietic feline intestinal carcinoma cases were histopathologically evaluated. In contrast with prior reports, large intestinal (LI) carcinoma was observed with greater frequency (61 %) relative to small intestinal (SI) carcinoma (35 %). There was a significant association between intestinal location and animal gender. Of males examined, 83 % had LI carcinoma, while no such trend was observed in females. Previously described associations between Siamese breed and intestinal carcinoma could not be definitively confirmed, although the Siamese breed may be predisposed to SI carcinoma location. Of all carcinomas examined in this study, 62 % were classified as adenocarcinoma, although mucinous adenocarcinoma (28 %) and solid carcinoma (11 %) were also identified. Tumours were all moderately or poorly differentiated. When considered by intestinal location and histopathologic classification, LI adenocarcinoma was associated with significantly advanced mean age (13 years) when compared to SI adenocarcinoma and LI mucinous adenocarcinoma (mean, 9 years in both cases), which were also frequently encountered. To determine whether EHS might play a role in feline intestinal neoplasia, Helicobacter genus-and species-specific fluorescence in situ hybridization was performed. Of these carcinoma cases, 56 % were positive for Helicobacter spp. and one or more speciesspecific assay for Helicobacter bilis, Helicobacter canis or Helicobacter marmotae. The presence of EHS was significantly associated with both LI location (68 %) and mucinous adenocarcinoma (92 %). These findings suggest a role for intestinal bacteria in non-haematopoietic feline intestinal neoplasia.

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“…Paraneoplastic syndromes, anemia, clinical alterations due to intestinal obstruction, and malabsorption may be associated with gastrointestinal neoplasia (LAROCK; GINN, 1997;COHEN, POST, 1999;CRAWSHAW et al, 1998;SÁ, 2016). The clinician and surgeon need to consider among the differential diagnoses the ulceroproliferative processes of inflammatory bowel disease, gastrointestinal infectious processes and other gastrointestinal neoplasms, such as lymphoma and adenocarcinoma (TURK et al, 1981;HEAD et al, 2002).…”

Section: Main Clinical Presentation In Dogs With Gastrointestinal Neomentioning

confidence: 99%

“…Intestinal carcinomas are the most common gastrointestinal neoplasms in dogs, they are AE1/AE3 cytokeratin positive, negative vimentin, and may present areas of metaplastic production of the osteoid matrix secondary to the production of osteoinductive cytokines such as the β-transglobulin growth factor, fibroblasts growth factor, and insulin-like factors 1 and 2 (TURK et al, 1981).…”

Section: Intestinal Osteosarcomamentioning

confidence: 99%

The importance of clinical, histopathological and immunohistochemical marking for differential diagnosis of non-hematopoietic gastrointestinal mesenchymal neoplasms in dogs: literature review

Leandro

Freitas

Sá

2017

Braz. J. Vet. Res. Anim. Sci.

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Gastrointestinal neoplasms in dogs represent a challenge for the veterinary clinician and surgeon as they are mostly malignant and when the owner notices the primary clinical changes the disease may already be in an advanced stage. Due to the high clinical and histopathological similarity between mesenchymal gastrointestinal neoplasms, it is often impossible to establish the definitive morphological diagnosis using light microscopy alone. In addition, there are only a few articles describing the anatomopathological and immunohistochemical characteristics, which make its complete characterization urgent and relevant in our context in order to assist the veterinary clinician, surgeon, and pathologist in establishing a precise diagnosis of these tumors. Keywords: C-KIT. Sarcoma. Stomach. Intestine. Colon. Rectum. ResumoAs neoplasias gastrointestinais em cães representam casos desafiantes ao clínico e cirurgião, pois são em sua maioria malignas e, quando as primeiras alterações clínicas são notadas pelo proprietário do animal, a doença pode estar em estágio de desenvolvimento muito avançado. Devido à elevada similaridade clínica e histopatológica entre as neoplasias gastrointestinais mesenquimais, muitas vezes não é possível estabelecer o diagnóstico morfológico definitivo apenas com a microscopia de luz. Acrescenta-se que são poucos os artigos que descrevem as características anatomopatológicas e imuno-histoquímicas das neoplasias mesenquimais gastrointestinais que acometem os cães, o que torna premente a caracterização destas em nosso contexto, com o intuito de auxiliar clínico, cirurgião e patologista veterinário a estabelecer o diagnóstico destes tumores.

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Nonhematopoietic Gastrointestinal Neoplasia in Cats: A Retrospective Study of 44 Cases

Cited by 66 publications

References 8 publications

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

Intestinal Adenocarcinoma in a Herd of Farmed Sika Deer (Cervus nippon)

Enterohepatic Helicobacter spp. in cats with non-haematopoietic intestinal carcinoma: a survey of 55 cases

The importance of clinical, histopathological and immunohistochemical marking for differential diagnosis of non-hematopoietic gastrointestinal mesenchymal neoplasms in dogs: literature review

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