Let R = K[X 1 , . . . , Xn] be a polynomial ring in n variables over a field K of charactersitic zero and d a K-derivation of R. Consider the isotropy group if d: Aut(R) d := {ρ ∈ Aut K (R)| ρdρ −1 = d}. In his doctoral thesis ([1]), Baltazar proved that if d is a simple Shamsuddin derivation of K[X 1 , X 2 ], then its isotropy group is trivial. He also gave an example of a non-simple derivation whose isotropy group is infinite. Recently, Mendes and Pan ([12]) generalized this result to an arbitrary derivation of K[X 1 , X 2 ] proving that a derivation of K[X 1 , X 2 ] is simple if, and only if, its isotropy group is trivial. In this paper, we prove that the isotropy group of a simple Shamsuddin derivation of the polynomial ring R = K[X 1 , . . . , Xn] is trivial. We also calculate other isotropy groups of (not necessarily simple) derivations of K[X 1 , X 2 ] and prove that they are finite cyclic groups.