Noninvasive Assessment of Endothelial Dysfunction in Egyptian Patients with Lupus Nephritis

Soliman, Ahmed; El-Khasab, Sahier Omar; Hammad, Hany; Magdy, Mohamed; Abu-Sheaishaa, Mahmoud Amin; Wahab, Hadeel Abd El; Hegazy, Mohamed Tharwat

doi:10.4103/1319-2442.336761

Cited by 2 publications

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“…An echocardiographic examination was performed by experienced echocardiographers on patients in the resting position. PH was defined as a PASP ≥ 40 mmHg [14] and PASP was calculated using the modified Bernoulli equation: PASP = 4 × (tricuspid systolic jet) 2 + right atrial pressure [14,15].…”

Section: Ph Definition and Pulmonary Artery Systolic Pressure (Pasp) ...mentioning

confidence: 99%

Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in Patients with Lupus Nephritis

Chen,

Guo,

Huang

et al. 2024

Medicina

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Background and Objectives: This study aimed to assess the prevalence, predictors, and outcomes of pulmonary hypertension (PH) in patients with lupus nephritis (LN). Materials and Methods: Baseline characteristics and clinical outcomes of 387 patients with LN were retrospectively collected from 2007 to 2017. PH was defined as pulmonary artery systolic pressure ≥40 mmHg assessed by resting transthoracic echocardiography. The primary endpoint was all-cause mortality. The secondary endpoint was renal events, defined as the doubling of baseline serum creatinine or end-stage renal disease. Associations between PH and outcomes were analyzed by Cox regression models. Results: A total of 15.3% (59/387) of patients with LN were diagnosed with PH, and the prevalence of PH was higher for patients with an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2 compared to those with an eGFR ≥ 30 mL/min/1.73 m2 (31.5% vs. 12.6%). Higher mean arterial pressure, lower hemoglobin, and lower triglyceride levels were associated with greater odds of having PH. After adjusting for relevant confounding variables, PH was independently associated with a higher risk for death (HR: 2.01; 95% CI: 1.01–4.00; p = 0.047) and renal events (HR: 2.07; 95% CI: 1.04–4.12; p = 0.039). Conclusions: PH is an independent risk factor for all-cause mortality and adverse renal outcomes in patients with LN.

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Section: Ph Definition and Pulmonary Artery Systolic Pressure (Pasp) ...mentioning

confidence: 99%

Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in Patients with Lupus Nephritis

Chen,

Guo,

Huang

et al. 2024

Medicina

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“…In SLE, immune-complex-mediated microvascular damage, secondary hypertension consequent to kidney involvement with activation of the RAAS, and the micro-thrombosis associated with endothelitis or aPL antibodies are the main mechanisms leading to ocular fundus lesions ( 22 ), which shares similarity with the pathogenesis of LN and NPSLE ( Figure 4 ) ( 70 , 71 ). In addition, endothelial dysfunction is an important feature and facilitating factor at the early stage of SLE ( 72 ). These associations lead to the hypothesis that the eye could serve as a window to detect other systemic damage.…”

Section: Associations Between Ocular Fundus and Other Systemic Involv...mentioning

confidence: 99%

“…Prior research has identified various non-invasive techniques for predicting LN, such as flow-mediated dilation of the brachial artery. Given the documented associations between ocular changes and LN, we believe that these changes could also serve as potential noninvasive screening methods for LN ( 72 ).…”

Section: Associations Between Ocular Fundus and Other Systemic Involv...mentioning

confidence: 99%

Ocular fundus changes and association with systemic conditions in systemic lupus erythematosus

Meng,

Wang,

Yang

et al. 2024

Front. Immunol.

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Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems. Ocular involvement is estimated to manifest in one-third of individuals with SLE, of which lupus retinopathy and choroidopathy represent the severe subtype accompanied by vision impairment. Advancements in multimodal ophthalmic imaging have allowed ophthalmologists to reveal subclinical microvascular and structural changes in fundus of patients with SLE without ocular manifestations. Both ocular manifestations and subclinical fundus damage have been shown to correlate with SLE disease activity and, in some patients, even precede other systemic injuries as the first presentation of SLE. Moreover, ocular fundus might serve as a window into the state of systemic vasculitis in patients with SLE. Given the similarities of the anatomy, physiological and pathological processes shared among ocular fundus, and other vital organ damage in SLE, such as kidney and brain, it is assumed that ocular fundus involvement has implications in the diagnosis and evaluation of other systemic impairments. Therefore, evaluating the fundus characteristics of patients with SLE not only contributes to the early diagnosis and intervention of potential vision damage, but also holds considerate significance for the evaluation of SLE vasculitis state and prediction of other systemic injuries.

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Noninvasive Assessment of Endothelial Dysfunction in Egyptian Patients with Lupus Nephritis

Cited by 2 publications

References 0 publications

Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in Patients with Lupus Nephritis

Prevalence, Predictors, and Outcomes of Pulmonary Hypertension in Patients with Lupus Nephritis

Ocular fundus changes and association with systemic conditions in systemic lupus erythematosus

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