Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system

Zheng, Yihao; Zhu, Xinming; Wang, Zhe; Hou, Zongyu; Gao, Fei; Nie, Rongzhi; Cui, Xiaoxia; She, Jiangbo; Peng, Bo

doi:10.3788/col201715.083001

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…A good correlation ( R 2 = 0.87) was obtained, and the average prediction error was 7.7%. Zheng et al developed a miniaturized wearable Raman spectroscopy system [ 110 ]. The main body consists of a miniature Raman spectrometer, a 785-nm laser diode as an illuminating source, lenses, a Czerny–Turner optical system, and a linear array charge coupled device (CCD).…”

Section: Methodologies For Noninvasive Glucose Sensing Utilizing Ementioning

confidence: 99%

Noninvasive Electromagnetic Wave Sensing of Glucose

Zhang

Liu

Jin

et al. 2019

Sensors

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Diabetic patients need long-term and frequent glucose monitoring to assist in insulin intake. The current finger-prick devices are painful and costly, which places noninvasive glucose sensors in high demand. In this review paper, we list several advanced electromagnetic (EM)-wave-based technologies for noninvasive glucose measurement, including infrared (IR) spectroscopy, photoacoustic (PA) spectroscopy, Raman spectroscopy, fluorescence, optical coherence tomography (OCT), Terahertz (THz) spectroscopy, and microwave sensing. The development of each method is discussed regarding the fundamental principle, system setup, and experimental results. Despite the promising achievements that have been previously reported, no established product has obtained FDA approval or survived a marketing test. The limitations of, and prospects for, these techniques are presented at the end of this review.

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Section: Methodologies For Noninvasive Glucose Sensing Utilizing Ementioning

confidence: 99%

Noninvasive Electromagnetic Wave Sensing of Glucose

Zhang

Liu

Jin

et al. 2019

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…This work indicates a very intriguing potential to investigate blood glucose levels for monitoring disease progression in a noninvasive manner. 46 These four studies show that Raman spectroscopy has a great potential to measure blood glucose levels in an accurate and minimally invasive manner. While this research requires repetition in large-scale human studies, the success shown here indicates this method could be considered in future work.…”

Section: Monitoring Blood Glucose Levels For Indicating Diabetesmentioning

confidence: 98%

Vibrational Spectroscopy for Detection of Diabetes: A Review

Ralbovsky

Lednev

2021

Appl Spectrosc

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Type II diabetes mellitus (T2DM) is a metabolic disorder that is characterized by chronically elevated glucose caused by insulin resistance. Although T2DM is manageable through insulin therapy, the disorder itself is a risk factor for much more dangerous diseases including cardiovascular disease, kidney disease, retinopathy, Alzheimerâs disease, and more. T2DM affects 450 million people worldwide and is attributed to causing over 4 million deaths each year. Current methods for detecting diabetes typically involve testing a personâs glycated hemoglobin levels as well as blood sugar levels randomly or after fasting. However, these methods can be problematic due to an individualâs levels differing on a day-to-day basis or being affected by diet or environment, and due to the lack of sensitivity and reliability within the tests themselves. Vibrational spectroscopic methods have been pursued as a novel method for detecting diabetes accurately and early-on in a minimally invasive manner. This review summarizes recent research, since 2015, which has used infrared or Raman spectroscopy for the purpose of developing a fast and accurate method for diagnosing diabetes. Based on critical evaluation of the reviewed work, vibrational spectroscopy has the potential to improve and revolutionize the way diabetes is diagnosed, thereby allowing for faster and more effective treatment of the disorder.

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“…Traditional methods of glucose measurement, such as blood glucose meters, are invasive and require frequent blood sampling, which can be inconvenient and painful [3]. A plethora of noninvasive glucose measurement techniques exist, including near-infrared (NIR) spectroscopy [4], mid-infrared (MIR) spectroscopy [5], photoacoustic (PA) spectroscopy [6], Raman spectroscopy [7], fluorescence spectroscopy [8], optical coherence tomography (OCT) [9], terahertz (THz) spectroscopy [10], and microwave sensing, all of which have been extensively researched. Microwave sensors offer a non-invasive alternative for glucose measurement, which has gained significant attention in recent years [11].…”

Section: Introductionmentioning

confidence: 99%

Glucose Concentration Monitoring Using Microstrip Spurline Sensor

Harnsoongnoen,

Buranrat

2023

Measurement Science Review

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This article reports a microstrip spurline sensor for glucose concentration monitoring. The microstrip spurline sensor is a low-cost and easy-to-fabricate device that uses printed circuit board (PCB) technology. It consists of a combination of four spurlines and transmission lines. The four spurlines are used to reject unwanted frequencies, while the transmission lines allow the desired frequencies to pass through. The resonance frequency (Fr) and reflection coefficient (S11) were recorded through meticulous simulations and experiments over a frequency range from 1.5 GHz to 4 GHz. In addition, the sensor was used to detect changes in glucose concentration, ranging from 0 mg/dL to 150 mg/dL. The findings of this study show that the antenna-based sensor proposed in this research can effectively measure glucose levels across the diabetes range, from hypoglycemia to normoglycemia to hyperglycemia, with a high degree of sensitivity of 7.82 x 10−3 dB/(mg/dL) and 233.33 kHz/(mg/dL).

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Noninvasive blood glucose detection using a miniature wearable Raman spectroscopy system

Cited by 10 publications

References 8 publications

Noninvasive Electromagnetic Wave Sensing of Glucose

Noninvasive Electromagnetic Wave Sensing of Glucose

Vibrational Spectroscopy for Detection of Diabetes: A Review

Glucose Concentration Monitoring Using Microstrip Spurline Sensor

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