Noninvasive Brain Tumor Imaging Using Red Emissive Carbonized Polymer Dots across the Blood–Brain Barrier

Liu, Yang; Liu, Junjun; Zhang, Jiayi; Li, Xiucun; Lin, Fangsiyu; Zhou, Nan; Yang, Bai; Lu, Laijin

doi:10.1021/acsomega.8b01169

Cited by 33 publications

(25 citation statements)

References 71 publications

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“…It can be clearly seen that the absolute fluorescence quantum yield of R‐CDs was 35.3%, which is higher than that of other R‐CDs reported in other papers. [ 46–48 ] The UV–vis spectrum of R‐CDs is shown in Figure 3(d). The absorption peak at 290 nm indicated that a graphite carbon structure was formed, [ 49 ] and the absorption peak centred at 550 nm was consistent with the optimum wavelength demonstrated in the photoluminescence (PL) spectrum of R‐CDs (Figure 5(b)).…”

Section: Resultsmentioning

confidence: 99%

One‐step preparation of red‐emitting carbon dots for visual and quantitative detection of copper ions

et al. 2020

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A one‐step solvothermal method for the preparation of carbon dots with red fluorescence (R‐CDs) was put forward, in which sodium citrate and formamide were chosen as precursors, while formamide was adopted as the solvent. The fluorescence emission peak of the as‐prepared R‐CDs remained the same (600 nm) when the excitation wavelength increased from 490 nm to 560 nm, and the fluorescence quantum yield is 35.3%. Furthermore, the fluorescence intensity of the as‐prepared R‐CDs could be selectively quenched by copper ions, and the mechanism of Cu2+ quenching R‐CDs is the combination of static and dynamic quenching. As a result, the R‐CDs were applied for the construction of a fluorescent sensor without any modification for the quantitative and visual detection of copper ions, which is a typical contaminant in water. The limit of detection for the fluorescent sensor was as low as 5 nmol/L, and it can be used to fast and directly confirm whether the content of copper ions in drinking water meets the criteria of the United States Environmental Protection Agency and the World Health Organization.

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Section: Resultsmentioning

confidence: 99%

One‐step preparation of red‐emitting carbon dots for visual and quantitative detection of copper ions

et al. 2020

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“…[30] Moreover, the red fluorescence of CPDs has less phototoxicity to tissues, lower biological fluorescence background, and higher tissue penetration ability than other shortwavelength fluorescence probes. [29,[31][32][33] Herein, we report the newly discovered functions of CPDs in inhibiting Aβ fibrillogenesis, rapidly disaggregating Aβ mature fibrils, and emitting enhanced red fluorescence once binding to Aβ aggregates. We have systematically investigated the effects of CPDs on Aβ 40 monomers/fibrils by an array of in vitro biophysical and biochemical methods and in vivo assays with an AD model of C. elegans CL2006 were conducted to investigate the multifunctionality of CPDs.…”

Section: Introductionmentioning

confidence: 98%

“…[27] Yang et al synthesized nitrogen-doped carbonized polymer dots (CPDs) as fluorescent probes for biological imaging in vitro and in vivo. [28,29] CPDs as a kind of carbon dots show many excellent characteristics, such as long-wavelength excitation and emission, good biocompatibility, desired blood brain barrier penetration ability, and high quantum yield. [30] Moreover, the red fluorescence of CPDs has less phototoxicity to tissues, lower biological fluorescence background, and higher tissue penetration ability than other shortwavelength fluorescence probes.…”

Section: Introductionmentioning

confidence: 99%

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Nitrogen‐Doped Carbonized Polymer Dots: A Potent Scavenger and Detector Targeting Alzheimer's β‐Amyloid Plaques

Gao

Wang

Dong

et al. 2020

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The fibrillization and deposition of β‐amyloid protein (Aβ) are recognized to be the pathological hallmarks of Alzheimer's disease (AD), which signify the need for the effective detection and inhibition of Aβ accumulation. Development of multifunctional agents that can inhibit Aβ aggregation, rapidly disaggregate fibrils, and image aggregates is one of the effective strategies to treat and diagnose AD. Herein, the multifunctionality of nitrogen‐doped carbonized polymer dots (CPDs) targeting Aβ aggregation is reported. CPDs inhibit the fibrillization of Aβ monomers and rapidly disintegrate Aβ fibrils by electrostatic interactions, hydrogen‐bonding and hydrophobic interactions with Aβ in a time scale of seconds to minutes. Moreover, the interactions make CPDs label Aβ fibrils and emit enhanced red fluorescence by the binding, so CPDs can be used for in vivo imaging of the amyloids in transgenic Caenorhabditis elegans CL2006 as an AD model. Importantly, CPDs are demonstrated to scavenge the in vivo amyloid plaques and to promote the lifespan extension of CL2006 strain by alleviating the Aβ‐triggered toxicity. Taken together, the multifunctional CPDs show an exciting prospect for further investigations in Aβ‐targeted AD treatment and diagnosis, and this study provides new insight into the development of carbon materials in AD theranostics.

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“…Biomaterials deliver distinctive unique tool including site specific drug delivery, early detection, therapy, imaging, and diagnosis of various diseases. 1 The diversity of these biomaterials provides unique biological and physiochemical characteristics for the variety of potential biomedical applications. 2 Hydrogel is a very commonly used material in the area of wound healing because of the ability to absorb a great amount of water and biological fluids, while remaining insoluble.…”

Section: Introductionmentioning

confidence: 99%

Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

et al. 2020

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Wound is the major health problem associated with skin damages and arises because of various types of topical injuries. Furthermore, wounds in patients with diabetes take a relatively long time to heal. Currently, herbal medicines have been extensively used for wound care and management. Here, we engineered polymeric hybrid hydrogel of dimethylaminoethyl acrylate and hyaluronic acid (pDMAEMA–HA), which was impregnated with a herbal extract of Didymocarpus pedicellatus . The developed polymeric hybrid hydrogel system can be used for effective therapy of incurable wounds. Therefore, the development of D. pedicellatus -impregnated pDMAEMA–HA (pDPi-DMAEMA–HA) hybrid hydrogel was accomplished by the synthesis of pDMAEMA–HA hydrogel via the optimization of various reaction parameters followed by impregnation of herbal drugs D. pedicellatus . The developed hydrogel composite was well characterized via various techniques, and swelling kinetics was performed to analyze the water uptake property. The swelling ratio was found to be 1600% in both types of hydrogels. To evaluate the wound healing of these polymeric hydrogels, the Wistar rats full-thickness excision wound model was utilized. The healing strength of hydrogels was determined using measurement of wound contraction and histopathological study. The results of wound healing by these polymeric hydrogels revealed that animals treated with the pDPi-DMAEMA–HA hybrid hydrogel group were found to have a higher level of wound closure as compared to marketed formulation as well as polymeric hybrid hydrogel. The histopathologic examinations implied that pDPi-DMAEMA–HA hybrid hydrogel and polymeric hybrid hydrogel-treated groups exhibited enhanced cutaneous wound repair as well as high level of cellular repair and maintenance compared to the standard group because of hyaluronic acid roles in various stages of wound repair.

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Noninvasive Brain Tumor Imaging Using Red Emissive Carbonized Polymer Dots across the Blood–Brain Barrier

Cited by 33 publications

References 71 publications

One‐step preparation of red‐emitting carbon dots for visual and quantitative detection of copper ions

One‐step preparation of red‐emitting carbon dots for visual and quantitative detection of copper ions

Nitrogen‐Doped Carbonized Polymer Dots: A Potent Scavenger and Detector Targeting Alzheimer's β‐Amyloid Plaques

Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

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