Noninvasive diagnosis and therapeutic effect evaluation of deep vein thrombosis in clinics by near-infrared spectroscopy

Abstract

Deep vein thrombosis (DVT) has become a severe disease with a rising incidence rate. The conventional diagnosis relies on complicated imaging modalities that may also involve invasive contrast agent injection and ionizing procedures (e.g., venography). Noninvasive near-infrared spectroscopy (NIRS) methods have been explored which required the DVT patients to follow some exercise protocols. Here, we attempt to use portable NIRS under patients' natural state for DVT diagnosis. Nine DVT patients and seven healthy subjects participated in NIRS measurements of concentration of oxy- and deoxy-hemoglobins (Δ[HbO2] and Δ[Hb]) relative to data on a tissue mimicking phantom at six particular sites of calves. It was found that Δ[HbO2] is significantly lower in DVT patients than healthy ones, whereas Δ[Hb] is distinctly higher. Moreover, after thrombolytic therapy, both Δ[HbO2] and Δ[Hb] in DVT calves assume a gradual convergence to the curves of healthy ones. This reveals the potential of NIRS for the noninvasive, continuous, and straightforward monitoring/therapeutic effect evaluation of DVT in clinics with appropriate bedside monitoring capability.

Longtime driving induced cerebral hemodynamic elevation and behavior degradation as assessed by functional near‐infrared spectroscopy and a voluntary attention test

“…Our fNIRS device consists of a flexible form probe and a control module coupled with a computer (Figure A). The probe was fixed over the subject's forehead with a black adjustable strap (Figure B).…”

Significant and sustaining elevation of blood oxygen induced by Chinese cupping therapy as assessed by near-infrared spectroscopy

“…Probing depth of NIRS can be centimeters sufficient for measurements of muscles in human subjects [17]. NIRS has been successfully utilized in a few therapeutic evaluation studies, such as massage therapy [18,19], electrical stimulation [20,21] and deep venous thrombosis [22].…”

Near-Infrared Spectroscopy-based Detector in Application of Intensive Care Unit Clinics

“…However, the conventional diagnosis relied on sophisticate imaging methodologies which might also induced invasive contrast agent injection and ionizing procedure. We proposed to develop a portable NIRS under patients' ease state for thrombus diagnosis, monitoring, and therapeutic effect evaluation [15,17]. The OPT101 embedded NIRS device was shown in Figure 3.…”

“…Then we reported the measurement algorithm for NIRS device to measure disease-sensitive hemodynamic parameters. After that, we reported some successful OPT101 embedded ICU-specific NIRS devices, including the one for early-diagnosis and therapeutic effect tracking of thrombus, noninvasive monitoring of shock patients' conditions, and the one for fatigue evaluation of long time working medical staffs [9,15,16,17]. Clinical experimental tests were carried out to fully test the reliabilities of these devices.…”

“…As an effective, nondestructive, and non-ionizing measurement technique, NIRS has attracted more and more researchers' attention. NIRS has been widely applied in various domains of science, including agriculture monitoring [12], food test [13], drug analysis [14], medical diagnosis [15], and etc., here we mainly focus on its successful applications in life science achieved by our group and collaborators.…”