1992
DOI: 10.1161/01.cir.85.1.368
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Noninvasive diagnosis of cardiac allograft rejection. Another of many searches for the grail.

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Cited by 40 publications
(10 citation statements)
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“…Unlike in the case of 99m Tc-pyrophosphate, a large amount of data support the clinical use of 111 In-antimyosin for the detection of acute or chronic diffuse myocardial damage in several clinical settings other than MI, such as allograft rejection in cardiac transplant recipients [25,26,27,28,29], doxorubicin-induced cardiotoxicity [20,30,31,32], acute myocarditis [19,33,34,35], various cardiomyopathies [21,36,37,38,39] or diseases secondary to myocardial involvement [40,41,42,43,44]. The performance of 111 In-antimyosin scanning in pathological conditions characterised by ongoing and diffuse myocardial necrosis is of potential clinical value considering that the serum concentration of the biological markers of myocardial injury may not be sufficient for the diagnosis or staging of the damage in these heart diseases.…”
Section: In-antimyosinmentioning
confidence: 99%
“…Unlike in the case of 99m Tc-pyrophosphate, a large amount of data support the clinical use of 111 In-antimyosin for the detection of acute or chronic diffuse myocardial damage in several clinical settings other than MI, such as allograft rejection in cardiac transplant recipients [25,26,27,28,29], doxorubicin-induced cardiotoxicity [20,30,31,32], acute myocarditis [19,33,34,35], various cardiomyopathies [21,36,37,38,39] or diseases secondary to myocardial involvement [40,41,42,43,44]. The performance of 111 In-antimyosin scanning in pathological conditions characterised by ongoing and diffuse myocardial necrosis is of potential clinical value considering that the serum concentration of the biological markers of myocardial injury may not be sufficient for the diagnosis or staging of the damage in these heart diseases.…”
Section: In-antimyosinmentioning
confidence: 99%
“…Also various biochemical markers, such as neopterines [ 3 ], prolactin [ 4 ], urinary polyamines [ 5 ], beta 2-microglobulins [ 6 ] and brain natriuretic peptide (BNP) [ 7 ] have been suggested for this purpose. However, none of the above methods or markers has proven sensitive or specific enough to replace endomyocardial biopsy [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…For the cytoimmunologic monitoring which was based primarily on the visual detection of lymphoblasts and activated lymphocytes in cytospins of a mononuclear concentrate of peripheral blood [3,4], high sensitivities and specificities in a range over 90% were reported [4]. These results could not be reproduced by others [5,6], even when the monitoring was supplemented by flow cytometric, immunophenotypic detection of activated forms of lymphocytes. The issue of whether or not the cytoimmunologic monitoring provided a valuable diagnostic information after heart transplantation is unresolved up to now.…”
Section: Discussionmentioning
confidence: 99%
“…They reported a high sensitivity and specificity for rejection detection by visual counting of lymphoblasts and activated lymphocytes in a stained cytospin of concentrated mononuclear blood cells. Others, however, could not reproduce the favorite results of these groups by using the same morphologically based approach or by immunophenotyping of activated lymphocytes by flow cytometry [5,6]. All body organs permanently shed soluble class I MHC antigens which can easily be detected in the circulation by enzyme immunoassay.…”
Section: Introductionmentioning
confidence: 99%