Noninvasive digital energy subtraction angiography with a channeling‐radiation x‐ray source

Gary, C. K.; Piestrup, M. A.; Boyers, D. G.; Pincus, C. I.; Pantell, R. H.; Rothbart, G. B.

doi:10.1118/1.597116

Cited by 17 publications

(7 citation statements)

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“…Narrow band x-ray beams from synchrotron sources costing hundreds of millions of dollars 5-7 have achieved highly detailed coronary images with impressively low contrast dosages. Other groups have suggested various exotic x-ray sources, including sources that rely on multiple MEV electrons 8,9 and laser-based x-ray sources 10 . Even if demonstrated, these technologies will, in all likelihood, be far too expensive for widespread use and would be difficult to incorporate into a standard catheterization laboratory.…”

Section: Dual-energy Subtraction Imagingmentioning

confidence: 99%

Dual-energy quasi-monochromatic x-ray source development

Richardson

2004

SPIE Proceedings

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There many instances where the use of a quasi-monochromatic x-ray source (QMS) would be an advantage in radiology. One instance is dual-energy imaging, where two images may be processed in order to enhance visualization of a particular element, typically iodine, but also possibly gadolinium. Another instance is fluoroscopy, where the radiation and/or contrast doses may be minimized by using a radiation source with an energy peak that lies just above the contrast K edge. The most straightforward method of implementing a QMS is to incorporate appropriate heavy elements into an x-ray tube anode and then to filter the resulting spectrum appropriately. Science Research Laboratory, Inc. has embarked on a program to develop anode materials that can withstand the power loadings encountered in a useful tube. Thus far, we have developed and tested one relevant anode material (erbia) and demonstrated that it could withstand a power of 0.25 MW/cm 2 at a tip speed of 3300cm/sec without harm. The destructive limit was determined to be at least a factor of two higher due to overwriting of the electron beam in certain regions. Under the condition of no overwriting, coating survivability should scale directly with tip speed. For futures studies we have designed an apparatus that increases the tip speed by a factor of 4.8. In the longer term, the tip speed could be increased by as much as a factor of 20.

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Section: Dual-energy Subtraction Imagingmentioning

confidence: 99%

Dual-energy quasi-monochromatic x-ray source development

Richardson

2004

SPIE Proceedings

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“…tracing element inside the sample (more details about the technique can be found elsewhere [2,4,6,7]). More quantitatively, the 2-D map of the intensity of the X-ray radiation transmitted by a sample irradiated at a normal incidence at a given photon wavelength can be written as I ðjÞ ðx; yÞ…”

Section: Article In Pressmentioning

confidence: 99%

“…For this method, known as coronary angiography [2,[5][6][7], the contrast agent usually used is iodine. Such studies have already been carried out using monochromatic radiation emitted by different kinds of X-ray sources, such as synchrotron [2,3] or conventional X-ray tubes [6,8]. Although synchrotron is presently the most performing source in terms of brightness, the cost and the size of this facility limit its use to large-scale research centers rather than hospitals.…”

Section: Introductionmentioning

confidence: 99%

Differential absorption imaging for elemental analysis of thin samples using a soft laser-plasma X-ray source

Laville¹,

Gizzi²,

Köster³

et al. 2005

Nuclear Instruments and Methods in Physics Research Section A:

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“…However, for a widespread use of this novel medical technique compact and low-cost radiation sources are required which can be operated in medical hospitals. Beside the development of compact synchrotron radiation sources also different X-ray production mechanisms (e.g., channeling radiation) have been discussed for DESA [8]- [11].…”

Section: Introductionmentioning

confidence: 99%

Novel digital K-edge imaging system with transition radiation from an 855-MeV electron beam

Hagenbuck

Backe

Clawiter

et al. 2001

IEEE Trans. Nucl. Sci.

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A novel K-edge imaging method has been developed at the Mainz Microtron MAMI aiming at a very efficient use of the transition radiation (TR) flux generated by the external 855 MeV electron beam in a foil stack. A fan-like quasi-monochromatic hard X-ray beam is produced from the ¦1 mrad wide TR cone with a highly oriented pyrolytic graphite (HOPG) crystal. The absorption of the object in front of a 30 mm ¢ 10 mm pn-CCD photon detector is measured at every pixel by a broad-band energy scan around the K-absorption edge. This is accomplished by a synchronous variation of the lateral crystal position and the electron beam direction which defines also the direction of the TR cone. The system has been checked with a phantom consisting of a 2.5 µm thick molybdenum sample embedded in a 136 or 272 µm thick copper bulk foil. A numerical analysis of the energy spectrum for every pixel demonstrates that data as far as ¦ 0.75 keV away from the K edge of molybdenum at 20 keV still improve the signal-to-noise ratio. Prospects are discussed to investigate the human lungs with xenon as a contrast agent at the available total primary photon flux of 2 ¢10 10 /(s¡ 0.1% bandwidth (BW)) only.

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Noninvasive digital energy subtraction angiography with a channeling‐radiation x‐ray source

Cited by 17 publications

References 0 publications

Dual-energy quasi-monochromatic x-ray source development

Dual-energy quasi-monochromatic x-ray source development

Differential absorption imaging for elemental analysis of thin samples using a soft laser-plasma X-ray source

Novel digital K-edge imaging system with transition radiation from an 855-MeV electron beam

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