Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI

Yin, Wang; Liu, Fang; Li, Xiaomei; Yang, Ling; Zhao, Shuang; Huang, Zixing; Huang, Youqun; Liu, Rongbo

doi:10.1016/j.ejrad.2011.03.045

Cited by 117 publications

(113 citation statements)

References 28 publications

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“…Lower medullary R 2 * values in acute renal transplant rejection (27) may represent higher oxygen bioavailability in the intrinsically hypoxic medulla secondary to impaired metabolism and halted tubular transport function (28). BOLD has also been used to study renal oxygenation in several animal models of diabetic nephropathy (29,30). Renal oxygenation likely changes in only advanced disease, because lower oxygenation is observed in the outer medulla of rats with diabetic nephropathy (29), but not in prediabetic, obese swine (31).…”

Section: Blood Oxygen Level-dependent Mrimentioning

confidence: 99%

Renal Relevant Radiology

Ebrahimi

Textor

Lerman

2014

Clinical Journal of the American Society of Nephrology

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SummaryBecause of its noninvasive nature and provision of quantitative measures of a wide variety of physiologic parameters, functional magnetic resonance imaging (MRI) shows great potential for research and clinical applications. Over the past decade, application of functional MRI extended beyond detection of cerebral activity, and techniques for abdominal functional MRI evolved. Assessment of renal perfusion, glomerular filtration, interstitial diffusion, and parenchymal oxygenation turned this modality into an essential research and potentially diagnostic tool. Variations in many renal physiologic markers can be detected using functional MRI before morphologic changes become evident in anatomic magnetic resonance images. Moreover, the framework of functional MRI opened a window of opportunity to develop novel pathophysiologic markers. This article reviews applications of some well validated functional MRI techniques, including perfusion, diffusion-weighted imaging, and blood oxygen level-dependent MRI, as well as some emerging new techniques such as magnetic resonance elastography, which might evolve into clinically useful tools.

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Section: Blood Oxygen Level-dependent Mrimentioning

confidence: 99%

Renal Relevant Radiology

Ebrahimi

Textor

Lerman

2014

Clinical Journal of the American Society of Nephrology

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“…2,11,[24][25][26]40,[46][47][48][49][50] With few exceptions, renal hypoxia has been demonstrated by BOLD MRI in experimental models of diabetes mellitus, including streptozotocin-induced diabetes in the rat, Cohen diabetic rats, and db/db mice. 2,11,24,25,48 Of note, Peng et al 24 also found increased fat content in kidneys from db/db mice, which may have contributed to the observed reduction in T2* attributed to hypoxia.…”

Section: Diabetic Nephropathymentioning

confidence: 99%

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Neugarten¹,

Golestaneh²

2014

IJNRD

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Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.

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“…Renal oxygenation is a dynamic characteristic that is influenced by a number of local and systemic factors, and may vary at different disease stages. 24 Dynamic monitoring of renal oxygenation changes with noninvasive BOLD MRI would be useful throughout treatment. BOLD MRI may provide useful information for assessing the effect of pharmacological interventions and adjusting medication regimens.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

et al. 2015

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Objectives: To use blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) to evaluate renal oxygenation in patients with primary nephrotic syndrome (PNS), and test the hypothesis that renal tissue oxygenation correlates with renal function, tubulointerstitial alterations and treatment response. Methods: Patients with untreated first-onset PNS and healthy control subjects underwent BOLD MRI. Blood and urine samples were obtained on the day of MRI, and patients underwent renal biopsy the day after MRI. Renal tubulointerstitial damage scores (TIDS) were determined using Katafuchi criteria. All patients received corticosteroids within 7 days after MRI and were followed up for 12 months. Results: Medullary R2* values were significantly lower in patients with PNS (n ¼ 20) than controls (n ¼ 18). Medullary R2* values were negatively correlated with estimated glomerular filtration rates and positively correlated with TIDS in patients with PNS. There were no significant differences in medullary or cortical R2* values when patients were classified according to treatment response.

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Noninvasive evaluation of renal oxygenation in diabetic nephropathy by BOLD-MRI

Cited by 117 publications

References 28 publications

Renal Relevant Radiology

Renal Relevant Radiology

Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Noninvasive evaluation of renal oxygenation in primary nephrotic syndrome with blood oxygen level dependent magnetic resonance imaging: Initial experience

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