Noninvasive Imaging for the Evaluation of Non-Alcoholic Fatty Liver Disease Spectrum

Liu, Qianjiao; Nie, Hong-Fang; Xu, Hengtian; Wang, Pingxian; Lei, Pinggui

doi:10.3348/kjr.2020.0492

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…In 7% of normal-weight (lean) individuals most commonly in females at a younger age and with normal liver enzymes, NAFLD is present 18 . Patients with NAFLD have approximately 50% hypertension, 50-90% hyperlipidemia, 30-50% T2DM, and 80-90% obesity while 62% have high triglyceride levels and 54% have reduced high-density lipoprotein cholesterol (HDL-C) levels 19 . Principal factors related to NAFLD are Diabetes mellitus type 2 (DM-2) and obesity 20 .…”

Section: Introductionmentioning

confidence: 99%

Role of Ultrasound in the Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

Salam,

Malik,

Farid

et al. 2024

PJMHS

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Background: The most prevalent liver illness, nonalcoholic fatty liver disease (NAFLD), is characterized by abnormal fat buildup in the hepatocytes without a substantial alcohol consumption history or secondary causes of fatty liver disease. Aim: This study aims to assess ultrasound's diagnostic utility in NAFLD. Material and Method: In the Hayatabad Medical Complex (HMC) in Peshawar, Pakistan, a cross sectional study with convenient sampling technique was conducted over six-month. This study received permission from the Institutional Research and Ethical Review Board (IREB) of HMC Hospital, and Open-Epi determined the sample size of 250 patients with a 95% confidence interval and a 5% margin of error. A certified sinologist conducted the abdominal ultrasound. The right arm was extended to its maximum abduction while the participants were positioned in the dorsal decubitus position. Using a right intercostal technique, the right liver lobe was seen, and a representative parenchymal region was identified without compromising the main vascular. The data were gathered through Questionnaire and analyzed using SPSS version 26. Results: There were 250 participants, with 55.4% men and 44.2% women. Patients between 40 and 49 accounted for 38.4% of the affected population. The most common conditions among patients with NAFLD were mild severity (49%) and abdominal discomfort (47.4%). Only (8%) of participants had liver cirrhosis before NAFLD while (91.6%) of patients lacked liver cirrhosis before NAFLD. When treating suspected NAFLD, 83.3 percent of patients preferred the Ultrasound modality initially, and more patients received a primary ultrasound diagnosis. Practical Implication: Ultrasound is the most commonly used modality because of their availability and low cost but its role in NAFLD is not fully diagnosed and evaluated. This study aims to evaluate the proper use of the Ultrasound modality in NAFLD for the benefits of patients to be diagnosed initially with Ultrasound so that it may not lead to a serious problem. Conclusion: A valuable non-invasive imaging technique for the diagnosis of non-alcoholic fatty liver disease (NAFLD) is ultrasound. Most patients first favor ultrasound, which is considered the leading imaging modality for NAFLD suspicion. The majority of NAFLD patients were middle-aged and male. Keywords: Abdominal pain, Fatigue, Liver cirrhosis, Non- Alcoholic Fatty Liver Disease, Ultrasound

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Section: Introductionmentioning

confidence: 99%

Role of Ultrasound in the Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

Salam,

Malik,

Farid

et al. 2024

PJMHS

View full text Add to dashboard Cite

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Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults

Yu,

Yang,

et al. 2024

Postgraduate Medical Journal

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Purpose To explore the relationship between liver fat content (LFC) and nonalcoholic fatty liver disease (NAFLD) and determine the new threshold of LFC to diagnose NAFLD. Methods The data from questionnaire survey, general physical examination, laboratory examination, and image examination were collected. Multivariate regression analysis, receiver operating characteristic curve analysis, smooth curve fitting, and threshold effect analysis were performed using the R software to investigate the relationship between LFC and NAFLD and to identify the new threshold of LFC to diagnose NAFLD. Results The prevalence of NAFLD was 30.42%, with a significantly higher prevalence in men than in women. Regression analyses demonstrated that LFC odds ratio [95% confidence interval (CI)] was 1.28 (95% CI: 1.24–1.31) in fully-adjust model. Analysis of the LFC quartile, with Q1 as a reference, revealed that the odds ratios of NAFLD were 1.47 (95% CI: 1.08–1.99), 2.29 (95% CI: 1.72–3.06), and 10.02 (95% CI: 7.45–13.47) for Q2, Q3, and Q4 groups, respectively. Smooth curve fitting and threshold effect analysis displayed a nonlinear relationship between LFC and NAFLD, and the threshold was 4.5%. The receiver operating characteristic curve indicated that when LFC was 4.5%, the area under curve (95% CI) was 0.80 (0.79–0.82), and the sensitivity and specificity of LFC in diagnosing NAFLD were 0.64% and 0.82%, respectively. Conclusion The relationship between LFC and NAFLD was sigmoidal, with an inflection point of 4.5%.

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Noninvasive Imaging for the Evaluation of Non-Alcoholic Fatty Liver Disease Spectrum

Cited by 2 publications

References 14 publications

Role of Ultrasound in the Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

Role of Ultrasound in the Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

Sigmoidal relationship between liver fat content and nonalcoholic fatty liver disease in Chinese adults

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