Noninvasive measurement of aluminium in human bone: Preliminary human study and improved system performance

Aslam,; Davis, Keith E.; Pejović‐Milić, Ana; Chettle, David R.

doi:10.1016/j.jinorgbio.2009.07.021

Cited by 12 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another analytical techniques used in analysis of metals in biological samples are, e.g., X-ray fluorescence (Pb and Sr in bones) [9,10]; Prompt gamma neutron activation (Cd in liver and kidney) neutron activation analysis (Al in bones) [11], ICP-AES (Cu, Co, Cr, Y, Yb, and Bi in biological samples) [12]; ICP-MS (trace elements in human urine) [13]; and HPLC-ICP-AES (Cu, Cd, and Zn in human liver) [14]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques

et al. 2014

View full text Add to dashboard Cite

BackgroundTrace element (TE) analysis in human tissue has the dual purpose of assessing environmental pollution and metabolism. In literature, bone TE analysis is common, but studies in intervertebral disc (IVD) tissue are lacking. The aim of the study was evaluation of the difference of TE concentration in intervertebral disc and bone in patients with degenerative changes. The comparison of the tissues differing in metabolism, blood perfusion, or separateness from adjoining tissues but playing similar biomechanical role and presenting some common morphological traits may shed new light on metabolism nuances, degenerative process, as well as accumulation potential of IVD in respect to bone.MethodsIn the study, we analyzed two types of samples: intervertebral disc (n =30, from 22 patients operated due to degenerative disc disease) and femoral bone (n =26, separately femoral head and neck, from 26 patients, acquired in total hip arthroplasty procedure in course of idiopathic osteoarthritis of the hip joint). In the samples we analyzed, with atomic absorption spectrometry, the concentrations of Pb, Ni, Mo, Cu, Mg, and Zn.ResultsThe element concentrations identified in bone are comparable to those presented in the literature. In the case of Pb, Ni, Mo, Mg, and Zn, the concentration in the bone was 2 to 25.8 times higher than that observed in the disc. Only the Cu concentration was higher in disc tissue than in bone. In disc tissue, fewer samples had TE concentrations below the detection threshold.We found significant differences in TE profiles in the compared tissues.ConclusionsThe results show that the disc could serve as a more stable compartment for evaluating TE concentration, especially for TEs that are environmentally related.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Another disadvantage is that it cannot be turned off, so heavy shielding is required even when the source is not in use. Another neutron source is the accelerator source used by McMaster University (Aslam et al 2008(Aslam et al , 2009b). This accelerator system requires a Tandetron accelerator, a big space, and it is not movable as we discussed in the introduction.…”

Section: Discussionmentioning

confidence: 99%

Development of a transportable neutron activation analysis system to quantify manganese in bonein vivo: feasibility and methodology

et al. 2013

View full text Add to dashboard Cite

This study was conducted to investigate the methodology and feasibility of developing a transportable neutron activation analysis (NAA) system to quantify manganese (Mn) in bone using a portable deuterium–deuterium (DD) neutron generator as the neutron source. Since a DD neutron generator was not available in our laboratory, a deuterium–tritium (DT) neutron generator was used to obtain experimental data and validate the results from Monte Carlo (MC) simulations. After validation, MC simulations using a DD generator as the neutron source were then conducted. Different types of moderators and reflectors were simulated, and the optimal thicknesses for the moderator and reflector were determined. To estimate the detection limit (DL) of the system, and to observe the interference of the magnesium (Mg) γ line at 844 keV to the Mn γ line at 847 keV, three hand phantoms with Mn concentrations of 30 parts per million (ppm), 150 ppm, and 500 ppm were made and irradiated by the DT generator system. The Mn signals in these phantoms were then measured using a 50% high-efficiency high-purity germanium (HPGe) detector. The DL was calculated to be about 4.4 ppm for the chosen irradiation, decay, and measurement time. This was calculated to be equivalent to a DL of about 3.3 ppm for the DD generator system. To achieve this DL with one 50% high-efficiency HPGe detector, the dose to the hand was simulated to be about 37 mSv, with the total body equivalent dose being about 23μSv. In conclusion, it is feasible to develop a transportable NAA system to quantify Mn in bone in vivo with an acceptable radiation exposure to the subject.

show abstract

“…The current work is a spinoff of a study measuring aluminum in human hand bone in AD and control subjects using IVNAA. The neutron activation analysis facility at McMaster University has been optimized and previously utilized for in vivo measurement of several major and minor elements in the human hand bone (Aslam et al 2008, 2009, Mostafaei et al 2015. A tandem accelerator is used to produce thermal neutrons via the 7 Li(p,n) 7 Be reaction.…”

Section: Methodsmentioning

confidence: 99%

In vivoneutron activation study of the short-term kinetic behaviour of sodium and chlorine in the human hand

et al. 2016

View full text Add to dashboard Cite

The time-dependent behaviour of sodium and chlorine was studied as a spinoff from a study of aluminum in the hand of subjects suffering from Alzheimer's disease and a control group, involving 15 Alzheimer's and 16 control subjects with an age range of 63-89 years. This was achieved using the in vivo neutron activation analysis system developed at McMaster University for the non-invasive measurement of aluminum, where a subject's hand is placed in a beam of accelerator-based thermalized neutrons, which activates elements by neutron capture. Following irradiation, the subject's hand is placed in a detection system comprising 9 NaI(Tl) detectors arranged in a 4π geometry to measure activated elements. The redistribution half-lives of the activation products Na andCl from the hand were determined after correction for the physical half-life, by means of sequential analysis of the residual activity in the hand. The kinetic behaviours of sodium and chlorine were best characterized by an exponential function corresponding to the rapidly exchangeable pool. The mean redistribution half-lives from the hand for sodium and chlorine in the control subjects were 40.5 ± 17.4 min and 24.2 ± 8.5 min, respectively. For Alzheimer's disease subjects the mean redistribution half-lives were 58.2 ± 36.1 min for sodium and 33.6 ± 16.7 min for chlorine. There was no significant difference in chlorine and sodium redistribution half-lives between the Alzheimer's disease and control group subjects. These results are promising, given that the irradiation and counting protocol were optimized for the aluminum study, rendering them suboptimal for analyzing other elements and their rate of change with time. Further improvements include optimizing the irradiation protocol, longer counting times, and measuring the activity in the un-irradiated hand in various time intervals following irradiation.

show abstract

Noninvasive measurement of aluminium in human bone: Preliminary human study and improved system performance

Cited by 12 publications

References 39 publications

Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques

Comparison of trace element concentration in bone and intervertebral disc tissue by atomic absorption spectrometry techniques

Development of a transportable neutron activation analysis system to quantify manganese in bonein vivo: feasibility and methodology

In vivoneutron activation study of the short-term kinetic behaviour of sodium and chlorine in the human hand

Contact Info

Product

Resources

About