Mechanics of Breathing 2014
DOI: 10.1007/978-88-470-5647-3_14
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Noninvasive Measures of Lung Structure and Ventilation Heterogeneity

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“…Analysis of the concentration-normalized phase III slopes (Sn III ) from the expirogram of each breath (termed Sn III analysis) provides further insights into the mechanisms contributing to ventilation inhomogeneity (also referred to as ventilation heterogeneity). Ventilation inhomogeneity can be partitioned into diffusionconvection-dependent inhomogeneity (DCDI) within the region of acinar airways (S acin ), which is driven by structural asymmetries within the region of the acinus, and to convectiondependent inhomogeneity (CDI) in the peripheral conducting airways (S cond ) , which is driven by differences in the mechanical properties (or time constants) of the more proximal conducting airways (25). Recent publications have highlighted the changes in MBNW indices with age (14,19,26,27).…”
Section: Introductionmentioning
confidence: 99%
“…Analysis of the concentration-normalized phase III slopes (Sn III ) from the expirogram of each breath (termed Sn III analysis) provides further insights into the mechanisms contributing to ventilation inhomogeneity (also referred to as ventilation heterogeneity). Ventilation inhomogeneity can be partitioned into diffusionconvection-dependent inhomogeneity (DCDI) within the region of acinar airways (S acin ), which is driven by structural asymmetries within the region of the acinus, and to convectiondependent inhomogeneity (CDI) in the peripheral conducting airways (S cond ) , which is driven by differences in the mechanical properties (or time constants) of the more proximal conducting airways (25). Recent publications have highlighted the changes in MBNW indices with age (14,19,26,27).…”
Section: Introductionmentioning
confidence: 99%