Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system

Petrova, Irina Y.; Petrov, Yuriy; Esenaliev, Rinat O.; Deyo, Donald J.; Cicenaite, Inga; Prough, Donald S.

doi:10.1364/oe.17.007285

Cited by 55 publications

(48 citation statements)

References 15 publications

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“…15 The oxygenated blood that subsequently flows into the veins may lead to HbT and SO 2 increases. 2,36 The current fPAM system found that the times to peak HbT and SO 2 were shorter in the MI arterioles than in veins under different stimulation intensities. To transfer a significant amount of HbT and SO 2 into the activation region, shorter times are needed to reach peak HbT and SO 2 in MI arterioles than in veins.…”

Section: Discussionmentioning

confidence: 92%

“…To transfer a significant amount of HbT and SO 2 into the activation region, shorter times are needed to reach peak HbT and SO 2 in MI arterioles than in veins. 15,36,37 Moreover, the greater increases in the HbT and SO 2 levels also indicate increased CBF. 32 This finding of dissociation of the HbT and CBV responses strongly suggests that Grubb's relationship between CBF and CBV [CBV ¼ 0.8 × CBF (Ref.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Liao

2012

J. Biomed. Opt

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Abstract. The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate single cerebral blood vessels of rats after left forepaw stimulation. In this system, we analyzed the spatiotemporal evolution of the HRFs of the total hemoglobin concentration (HbT), cerebral blood volume (CBV), and hemoglobin oxygen saturation (SO 2 ). Changes in specific cerebral vessels corresponding to various electrical stimulation intensities and durations were bilaterally imaged with 36 × 65-μm 2 spatial resolution. Stimulation intensities of 1, 2, 6, and 10 mA were applied for periods of 5 or 15 s. Our results show that the relative functional changes in HbT, CBV, and SO 2 are highly dependent not only on the intensity of the stimulation, but also on its duration. Additionally, the duration of the stimulation has a strong influence on the spatiotemporal characteristics of the HRF as shorter stimuli elicit responses only in the local vasculature (smaller arterioles), whereas longer stimuli lead to greater vascular supply and drainage. This study suggests that the current fPAM system is reliable for studying relative cerebral hemodynamic changes, as well as for offering new insights into the dynamics of functional cerebral hemodynamic changes in small animals.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Liao

2012

J. Biomed. Opt

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“…Noninvasive measurement of other important physiologic variables 1,2 including total hemoglobin concentration can be performed as well, because infants (in particular, LBW and VLBW infants) often have abnormal levels of total hemoglobin concentration. We developed, built, and tested in animal and clinical studies optoacoustic systems for noninvasive measurement and continuous monitoring of cerebral oxygenation and other important physiologic variables [3][4][5][6][7][8][9][10][11][12][13][14] . The optoacoustic technique combines the advantages of both optical (high contrast) and ultrasound (high resolution) techniques and (using well-established difference in the absorption spectra of oxy-and deoxyhemoglobin 15 ) can be used for accurate monitoring of cerebral oxygenation and other important physiologic variables in adults, children, and infants.…”

Section: Introductionmentioning

confidence: 99%

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

et al. 2015

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Premature, very-low-birth-weight (VLBW; ≤1500 g) and low-birth-weight (LBW; 1500-2499 g) infants are at increased risk for severe neurological disability. 25-50% of the 63,000 VLBW infants born annually in the USA have major longterm cognitive or neurobehavioral deficits in which cerebral hypoxia plays an important role. At present, no technology is capable of noninvasive, accurate monitoring of cerebral oxygenation in newborns. We proposed to use an optoacoustic technique for noninvasive cerebral hypoxia monitoring by probing the superior sagittal sinus (SSS). Recently, we developed and built a medical grade, multi-wavelength, near-infrared optoacoustic system suitable for neonatal applications. We designed and built an adjustable patient interface for neonates with VLBW, LBW, and normal weight (NBW) that provides single or continuous measurements of the SSS blood oxygenation in both the reflection and transmission modes. We performed pilot clinical tests of the system in VLBW, LBW, and NBW hemodynamically stable infants admitted to the neonatal intensive care unit. The system was capable of detecting SSS signals through the open anterior and posterior fontanelles and through the skull and allowed for monitoring of the SSS blood oxygenation in both modes. To the best of our knowledge this paper reports for the first time detection of optoacoustic signals from human cerebral blood vessels in both the transmission mode and the reflection mode. Analysis of the signals allows for noninvasive measurement of cerebral venous blood oxygenation in newborns in both modes. The transmission mode can be used for accurate measurement of the total hemoglobin concentration as well. The method and system proposed in this study can be used for optoacoustic human brain imaging, tomography, and mapping.

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“…We have previously used optoacoustics to monitor blood oxygenation in the SSS of adult humans, 14 neonates, 15 and sheep, 11,13 as well as in the human IJV. 12…”

Section: Introductionmentioning

confidence: 99%

Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system

et al. 2013

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Monitoring of cerebral venous oxygenation is useful to facilitate management of patients with severe or moderate traumatic brain injury (TBI). Prompt recognition of low cerebral venous oxygenation is a key to avoiding secondary brain injury associated with brain hypoxia. In specialized clinical research centers, jugular venous bulb catheters have been used for cerebral venous oxygenation monitoring and have demonstrated that oxygen saturation < 50% (normal range is 55-75%) correlates with poor clinical outcome. We developed an optoacoustic technique for noninvasive monitoring of cerebral venous oxygenation. Recently, we designed and built a novel, medical grade optoacoustic system operating in the near-infrared spectral range for continuous, real-time oxygenation monitoring in the superior sagittal sinus (SSS), a large central cerebral vein. In this work, we designed and built a novel SSS optoacoustic probe and developed a new algorithm for SSS oxygenation measurement. The SSS signals were measured in healthy volunteers during voluntary hyperventilation, which induced changes in SSS oxygenation. Simultaneously, we measured exhaled carbon dioxide concentration (EtCO 2 ) using capnography. Good temporal correlation between decreases in optoacoustically measured SSS oxygenation and decreases in EtCO 2 was obtained. Decreases in EtCO 2 from normal values (35-45 mmHg) to 20-25 mmHg resulted in SSS oxygenation decreases by 3-10%. Intersubject variability of the responses may relate to nonspecific brain activation associated with voluntary hyperventilation. The obtained data demonstrate the capability of the optoacoustic system to detect in real time minor changes in the SSS blood oxygenation.

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Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system

Cited by 55 publications

References 15 publications

Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

Cerebral venous blood oxygenation monitoring during hyperventilation in healthy volunteers with a novel optoacoustic system

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