2016
DOI: 10.2147/ijn.s115357
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Noninvasive monitoring of early antiangiogenic therapy response in human nasopharyngeal carcinoma xenograft model using MRI with RGD-conjugated ultrasmall superparamagnetic iron oxide nanoparticles

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Cited by 18 publications
(4 citation statements)
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“…In contrast, few iron-positive cells were detected in the kidney and muscle tissue sections by Prussian blue staining. These experimental results are consistent with those of previously published studies [ 26 , 32 ]. This phenomenon could be explained by nanoparticle clearance mediated by macrophages in the liver and spleen.…”
Section: Discussionsupporting
confidence: 94%
“…In contrast, few iron-positive cells were detected in the kidney and muscle tissue sections by Prussian blue staining. These experimental results are consistent with those of previously published studies [ 26 , 32 ]. This phenomenon could be explained by nanoparticle clearance mediated by macrophages in the liver and spleen.…”
Section: Discussionsupporting
confidence: 94%
“…Similarly, Puig J et al [21] contended IVIM-parametric were useful for characterizing the diffusion and perfusion features of glioblastoma, in which they observed a signi cant positive correlation between f and microvessel density as well as a negative correlation between cellularity and D. As con rmed by histology, parametric f and D* were associated sigini cantly with the angiogenesis degree of microvessels and determined upon the attenuation of microvascular, in particular, the basement membrane thickness coupled with pericyte coverage. Thus, D* parametric was accounted as a proportional correlation with the average blood velocity as well as capillary segment length [22][23][24] . These founding indirectly revealed that regions with the highest cellularity in tumor tissues always correlated with the maximum vascularity area, and maps of IVIM-parametric could also highlight tumor's heterogeneous pathological features generally.…”
Section: Discussionmentioning
confidence: 99%
“…For Prussian blue staining, paraffin-embedded tissue sections were incubated with potassium ferrocyanide solution and hydrochloric acid (V:V = 1:1), and counterstained with 0.1% nuclear fast red for 5 min as described in vitro [27]. The pathologist who performed the immunohistochemistry analysis was blinded to the experimental groups.…”
Section: Methodsmentioning
confidence: 99%