Noninvasive Neuromodulation in Migraine

Blech, Benzion; Starling, Amaal J.

doi:10.1007/s11916-020-00914-3

Cited by 18 publications

(15 citation statements)

References 43 publications

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“…In recent years, transcranial magnetic stimulation (TMS) has been widely used in the treatment of neuromodulation of the brain because of its efficacy in modulating the activity of cortical areas (Mehta et al, 2019;Blech and Starling, 2020;Chung et al, 2020;Mimura et al, 2021). The therapeutic mechanism of TMS is to generate subthreshold or suprathreshold currents in the human cerebral cortex through electromagnetic induction (Lefaucheur et al, 2014;Rossini et al, 2015), thereby modulating the excitability of the cerebral cortex.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of repetitive transcranial magnetic stimulation on cognitive impairment in stroke patients: a systematic review and meta-analysis

Gong

Peng

et al. 2023

Front. Hum. Neurosci.

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BackgroundIn recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a noninvasive and painless treatment for post-stroke cognitive impairment (PSCI). However, few studies have analyzed the intervention parameters of cognitive function and the effectiveness and safety of rTMS for treating patients with PSCI. Thus, this meta-analysis aimed to analyze the interventional parameters of rTMS and evaluate the safety and effectiveness of rTMS for treating patients with PSCI.MethodsAccording to the PRISMA guidelines, we searched the Web of Science, PubMed, EBSCO, Cochrane Library, PEDro, and Embase to retrieve randomized controlled trials (RCTs) of rTMS for the treatment of patients with PSCI. Studies were screened according to the inclusion and exclusion criteria, and two reviewers independently performed literature screening, data extraction, and quality assessment. RevMan 5.40 software was used for data analysis.Results12 RCTs involving 497 patients with PSCI met the inclusion criteria. In our analysis, rTMS had a positive therapeutic effect on cognitive rehabilitation in patients with PSCI (P < 0.05). Both high-frequency rTMS and low-frequency rTMS were effective in improving the cognitive function of patients with PSCI by stimulating the dorsolateral prefrontal cortex (DLPFC), but their efficacy was not statistically different (P > 0.05).ConclusionsrTMS treatment on the DLPFC can improve cognitive function in patients with PSCI. There is no significant difference in the treatment effect of high-frequency rTMS and low-frequency rTMS in patients with PSCI between high-frequency and low-frequency rTMS.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=323720, identifier CRD 42022323720.

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Section: Introductionmentioning

confidence: 99%

Therapeutic effects of repetitive transcranial magnetic stimulation on cognitive impairment in stroke patients: a systematic review and meta-analysis

Gong

Peng

et al. 2023

Front. Hum. Neurosci.

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“…One of the recent innovations in migraine treatment was the detection of several types of neurostimulation for acute and preventive treatment [ 1 ]. The basic idea behind this is the stimulation of peripheral and cranial nerve structures or of the cortex to reduce migraine pain or to decrease migraine frequency.…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Neurostimulation Methods for Acute and Preventive Migraine Treatment—A Narrative Review

Evers

2021

JCM

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Neurostimulation methods have now been studied for more than 20 years in migraine treatment. They can be divided into invasive and non-invasive methods. In this narrative review, the non-invasive methods are presented. The most commonly studied and used methods are vagal nerve stimulation, electric peripheral nerve stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation. Other stimulation techniques, including mechanical stimulation, play only a minor role. Nearly all methods have been studied for acute attack treatment and for the prophylactic treatment of migraine. The evidence of efficacy is poor for most procedures, since no stimulation device is based on consistently positive, blinded, controlled trials with a sufficient number of patients. In addition, most studies on these devices enrolled patients who did not respond sufficiently to oral drug treatment, and so the role of neurostimulation in an average population of migraine patients is unknown. In the future, it is very important to conduct large, properly blinded and controlled trials performed by independent researchers. Otherwise, neurostimulation methods will only play a very minor role in the treatment of migraine.

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“…TEN is a well-tolerated method for subthreshold neurostimulation that is FDAapproved for brain-based disorders such as ADHD [46] and migraines [47], and also appears to have some effectiveness in major depressive disorder [42], post-traumatic stress disorder [48] and generalized anxiety disorder [49]. This is the first study to investigate the tolerability and effectiveness of TEN therapy in ASD, a disorder with many co-morbidities including anxiety and sleep disruption.…”

Section: Discussionmentioning

confidence: 99%

“…TEN applied to the trigeminal or vagus nerves is therapeutic for ADHD [46], migraine headache [47], major depressive disorder [42], post-traumatic stress disorder [48] and generalized anxiety disorder [49], among others. Furthermore, it is consistently reported to be well-tolerated without any AEs.…”

Section: An Alternative Treatment Approach To Modulate the Physiological Drivers Of Anxiety And Sleep Disruptionmentioning

confidence: 99%

Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings

Foldes

Jensen

Jacobson

et al. 2021

JPM

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Background: Autism spectrum disorder (ASD) is associated with anxiety and sleep problems. We investigated transdermal electrical neuromodulation (TEN) of the cervical nerves in the neck as a safe, effective, comfortable and non-pharmacological therapy for decreasing anxiety and enhancing sleep quality in ASD. Methods: In this blinded, sham-controlled study, seven adolescents and young adults with high-functioning ASD underwent five consecutive treatment days, one day of the sham followed by four days of subthreshold TEN for 20 min. Anxiety-provoking cognitive tasks were performed after the sham/TEN. Measures of autonomic nervous system activity, including saliva α-amylase and cortisol, electrodermal activity, and heart rate variability, were collected from six participants. Results: Self-rated and caretaker-rated measures of anxiety were significantly improved with TEN treatment as compared to the sham, with effect sizes ranging from medium to large depending on the rating scale. Sleep scores from caretaker questionnaires also improved, but not significantly. Performance on two of the three anxiety-provoking cognitive tasks and heart rate variability significantly improved with TEN stimulation as compared to the sham. Four of the seven (57%) participants were responders, defined as a ≥ 30% improvement in self-reported anxiety. Salivary α-amylase decreased with more TEN sessions and decreased from the beginning to the end of the session on TEN days for responders. TEN was well-tolerated without significant adverse events. Conclusions: This study provides preliminary evidence that TEN is well-tolerated in individuals with ASD and can improve anxiety.

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Noninvasive Neuromodulation in Migraine

Cited by 18 publications

References 43 publications

Therapeutic effects of repetitive transcranial magnetic stimulation on cognitive impairment in stroke patients: a systematic review and meta-analysis

Therapeutic effects of repetitive transcranial magnetic stimulation on cognitive impairment in stroke patients: a systematic review and meta-analysis

Non-Invasive Neurostimulation Methods for Acute and Preventive Migraine Treatment—A Narrative Review

Transdermal Electrical Neuromodulation for Anxiety and Sleep Problems in High-Functioning Autism Spectrum Disorder: Feasibility and Preliminary Findings

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