Noninvasive predictors of large varices in patients hospitalized with gastroesophageal variceal hemorrhage

Ismail, Faisal Wasim; Shah, Hasnain Ali; Salehiniya, Hamid; Abbas, Zaigham; Abid, Shahab; Mumtaz, Khalid; Jafri, Wasim

doi:10.1007/s12072-007-9034-1

Cited by 27 publications

(21 citation statements)

References 28 publications

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“…This study reported a mortality reduction to 7.5% with better monitoring. At our center, survival was over 90% in the pre-BCU and BCU data; similar results have been reported in other and our previous studies [10,22,23]. However, a trend of improvement in survival was observed in BCU data of 2007 up to 97%.…”

Section: Discussionsupporting

confidence: 90%

Impact of a bleeding care pathway in the management of acute upper gastrointestinal bleeding

Mumtaz

Kamani

Salehiniya

et al. 2011

Indian J Gastroenterol

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Section: Discussionsupporting

confidence: 90%

Impact of a bleeding care pathway in the management of acute upper gastrointestinal bleeding

Mumtaz

Kamani

Salehiniya

et al. 2011

Indian J Gastroenterol

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“…This in contrary to other studies where the IHM rate 8.7% is consistent with the experience from other centers. 28 Similar decline in the IHM rate has been reported in other studies. 29 The variation of the IHM for cirrhotic patients with variceal hemorrhage is likely related to the degree of underlying liver dysfunction, the use of life support systems such as blood, vasoactive agents, and endotracheal intubation, and the subsequent development of clinical complications including renal insufficiency, cardiopulmonary complications, and infection.…”

Section: Articlesupporting

confidence: 85%

“…30 Although IHM in cirrhotic patients with GI bleeding is declining 31,32 it is still associated with significant morbidity and mortality. 26,28 More than half of patients with GI bleeding have a comorbid disease mainly hypertension, diabetes mellitus, coronary artery diseases, and malignancies. 31 Clinical guidelines published in 2008 in Scotland cited a mortality rate of 4% in GI bleeding patients without comorbidities, with the mortality rate increasing 1.8 times in cases with heart failure, 3.8 times in cases with malignancy, and 2.0 times in cases with liver disease.…”

Section: Articlementioning

confidence: 99%

Risk scoring systems to predict in-hospital mortality in patients with acute variceal bleeding due to HCV-induced liver cirrhosis

Hassanien

El-Ghannam

El-Talkawy

et al. 2018

Gastroenterol Insights

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This study was designed to validate and to compare accuracy of the prognostic scores; mainly Child Turcotte Pugh (CTP), creatinine-modified Child Turcotte Pugh (CTP-Cr), model for end-stage liver disease (MELD), albumin bilirubin score (ALBI), and AIMS65, for the predicting clinical outcomes in cirrhotic Egyptian patients presenting with acute variceal bleeding (AVB). Retrospective single center study involving 725 patients presenting with AVB due to liver cirrhosis and HCV infection either alone or mixed with HBV infection. In hospital mortality prognostic scores were calculated; mainly CTP, modified CTP-Cr, MELD, ALBI, AIMS65. The endpoint is either patient improvement or death. 725 patients were included over 1-year period. 547 (75%) survived and 178 (25%) died. Patients presented with hematemesis (515/71%), melena (120/16.5%) or hematemesis and melena (90/12.5%). Those with hematemesis for the first time were 241 (33%) and recurrent attacks were 484 (66.8%). The non-survivors had significantly more incidence of shock on presentation, more blood transfused units, history of NSAIDS intake, more ICU admission days and were more likely to be Childs C. Child, modified CTP-Cr, MELD, ALBI and ALMS65 scoring systems showed significant difference between survivors and nonsurvivors. Liver specific scores (Child, MELD) and gastrointestinal bleeding scoring systems (ALBI, AIMS65) are useful in predicting clinical outcomes of AVB in cirrhotic patients. CTP-Cr score had the highest prognostic capability of in hospital mortality. Presence of active bleeding at time of endoscopy, more complications, old age, shock and higher CPT-Cr score are additional independent predictors of in hospital mortality.

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“…9 It is also a common cause of mortality amongst Pakistani population 10 and frequent cause of admission in our hospitals. 11 Portal hypertensive gastropathy is defined by mucosal and submucosal vascular ectasia in the absence of Inflammation. A lot of reasons counting modification in blood circulation in the spleen, humoral aspects and confined dysregulation of vascular quality have been concerned in the pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Cirrhosis

Kazi¹,

Abbasi²,

Naz³

2018

TPMJ

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ABSTRACT… Objectives:To investigate the histological changes in gastric mucosa of liver cirrhosis patients. Study design: Cross sectional study. Place and Duration: Department of Anatomy and Medicine, Gastroenterology unit, Isra University Hospital (June to December 2012). Subjects and Methods: 85 diagnosed cases of liver cirrhosis were selected according to inclusion and exclusion criteria. Specimen of 2 mm thickness was taken by punch biopsy from gastric body and antrum by endoscope. Tissues were fixed in 10% formaldehyde, 3-5 µ sections were stained with H & E for microscopy. Data was analyzed on SPSS version 21.0. Results: Age (mean ±SD) was noted as 47±11.5 years. Of 85, 56 (65.8%) were male and 29 (34.1%) female. Frequency of mild, moderate, severe and no gastropathy were noted in 52.94%, 34.12%, 4.71%, and 8.24% respectively. 9.4% of cases show capillary dilation and edematous lamina propria. Conclusion: Microscopy shows gastropathy in majority of specimens. Thick gastric mucosa, increased gland size and mucosa capillary dilation was noted. Key words:Liver Cirrhosis, Portal Gastropathy, Histology, Isra University.

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Noninvasive predictors of large varices in patients hospitalized with gastroesophageal variceal hemorrhage

Cited by 27 publications

References 28 publications

Impact of a bleeding care pathway in the management of acute upper gastrointestinal bleeding

Impact of a bleeding care pathway in the management of acute upper gastrointestinal bleeding

Risk scoring systems to predict in-hospital mortality in patients with acute variceal bleeding due to HCV-induced liver cirrhosis

Cirrhosis

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