2021
DOI: 10.1038/s41467-021-26026-z
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Noninvasive spinal stimulation safely enables upright posture in children with spinal cord injury

Abstract: In children with spinal cord injury (SCI), scoliosis due to trunk muscle paralysis frequently requires surgical treatment. Transcutaneous spinal stimulation enables trunk stability in adults with SCI and may pose a non-invasive preventative therapeutic alternative. This non-randomized, non-blinded pilot clinical trial (NCT03975634) determined the safety and efficacy of transcutaneous spinal stimulation to enable upright sitting posture in 8 children with trunk control impairment due to acquired SCI using withi… Show more

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Cited by 35 publications
(46 citation statements)
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“…Activation of cutaneous nociceptors and paraspinal muscle contractions are the main causes of discomfort during tSCS. Both types of discomfort have been reported in several studies, sometimes requiring discontinuation for several days (Hofstoetter et al, 2018; Keller et al, 2021; Manson et al, 2020). Our participants reported strong paraspinal muscle contractions and discomfort of electrical stimulation at higher amplitudes.…”
Section: Discussionmentioning
confidence: 90%
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“…Activation of cutaneous nociceptors and paraspinal muscle contractions are the main causes of discomfort during tSCS. Both types of discomfort have been reported in several studies, sometimes requiring discontinuation for several days (Hofstoetter et al, 2018; Keller et al, 2021; Manson et al, 2020). Our participants reported strong paraspinal muscle contractions and discomfort of electrical stimulation at higher amplitudes.…”
Section: Discussionmentioning
confidence: 90%
“…tSCS neuromodulation for the recovery of motor functions requires stimulation amplitudes at or near PRM reflex threshold to be effective (Hofstoetter et al, 2021; Inanici et al, 2021; Keller et al, 2021; Rath et al, 2018; Sayenko et al, 2019). PRM reflexes consist of a multi-segment superposition of H-reflexes and cutaneous afferent inputs (Freitas et al, 2022; Krenn et al, 2013; Minassian et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
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“…The limitation of tsPCS depends upon the anatomical space over the stimulation region as it may induce changes in the delivery [ 103 ] and period of stimulation due to the chance of overheating the skin [ 104 ]. Some studies have reported a rise in systolic blood pressure of over 60 mmHg with skin rupture in the stimulation region [ 105 ].…”
Section: Trans-spinal Pulsed Current Stimulation (Tspcs)mentioning
confidence: 99%