Noniterative microcomputer analysis of competing first- and m-order reactions by a constant time interval method

Bertrand, Roland; Dubois, Jessica; Toullec, Jean.

doi:10.1021/ac00225a021

Cited by 5 publications

(1 citation statement)

References 16 publications

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“…A microprocessor-based computer system for data acquisition and manipulations specifically designed for rapid kinetic studies has been reported by Holtzman (302), and Fasano and Nogar (303) have designed a useful multipurpose computer based data acquisition system. A method applicable to microcomputers for calculating the rate constants of competing firstand second-order reactions from data recorded at constant time intervals has been given by Bertrand et al (304). A discussion of preliminary statistical analysis of kinetic data has been given by Ellerton and Mayne (305).…”

Section: Instrumentation and Computersmentioning

confidence: 99%

Kinetic determinations and some kinetic aspects of analytical chemistry

Mottola¹,

Mark²

1982

Anal. Chem.

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KINETIC ASPECTS OF ANALYTICAL CHEMISTRYHoraclo A. Mottola was born in Buenos Aires, Argentina, and received undergraduate and graduate education at the University of Buenos Aires. He earned Licentiate and Doctoral degrees from the University of Buenos Aires and did predoctoral work with Professor Ernest B. Sandell at the University of Minnesota (Minneapolis). He spent two years at the University of Arizona (Tucson) as a postdoctoral research fellow In Professor Henry Freiser's research group. After teaching for two years at the University ot the Pacific (Stockton, CA), he joined OSU in the fall of 1967. Dr. Mottola's research interests include studies on the role of kinetics in analytical chemistry (including reaction reate determinations), analytical separations (solvent extraction and liquid-liquid chromatography), continuousflow analysis, and analytical application of photochromism.

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Section: Instrumentation and Computersmentioning

confidence: 99%

Kinetic determinations and some kinetic aspects of analytical chemistry

Mottola¹,

Mark²

1982

Anal. Chem.

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Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain

Khan

Thomas

2004

Archives of Toxicology

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Previous studies have shown that oral exposure of rats to polychlorinated biphenyls (PCBs) results in reduced 5-hydroxytryptamine (5-HT) concentrations in certain brain regions. In the present study, we investigated whether the PCB mixture Aroclor 1254 (0.33 mg/g body weight as a single oral dose) can inhibit the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in 5-HT synthesis, and reduce 5-HT concentrations in selected brain areas. In two separate experiments, Aroclor 1254 exposure consistently reduced TPH activity in the brainstem (7.2 and 8.7%), frontal cortex (17.4 and 14.8%), and hypothalamus (10.7 and 9.4%) without altering the rats' food intake or growth. Moreover, Aroclor 1254 accumulation in the frontal cortex demonstrated a negative correlation with TPH activity (correlation coefficient -0.82). In addition, 5-HT concentrations decreased in the brainstem and frontal cortex after Aroclor 1254 exposure by 9.1 and 19.7%, respectively. These results suggest that the Aroclor 1254-induced decreases in 5-HT concentrations in certain areas of the rat brain are due to inhibition of TPH activity, similar to our recent observations in Atlantic croaker, and that TPH is one of the targets of PCB neurotoxicity in both fish and mammals.

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Transport and accumulation of organochlorines in the ovaries of Atlantic croaker (Micropogonias undulatus)

J¹,

Thomas²

1996

Marine Environmental Research

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Noniterative microcomputer analysis of competing first- and m-order reactions by a constant time interval method

Cited by 5 publications

References 16 publications

Kinetic determinations and some kinetic aspects of analytical chemistry

Kinetic determinations and some kinetic aspects of analytical chemistry

Aroclor 1254 inhibits tryptophan hydroxylase activity in rat brain

Transport and accumulation of organochlorines in the ovaries of Atlantic croaker (Micropogonias undulatus)

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