Nonkeratinizing Undifferentiated Nasopharyngeal Carcinoma

Peterson, Brandon; Nelson, Brenda L.

doi:10.1007/s12105-012-0401-4

Cited by 16 publications

(18 citation statements)

References 5 publications

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“…Males made up the majority of both cohorts, a finding consistent with previous studies . It is unclear, however, why the frequency of males among NK‐NPSCC cohort (72.9%) was greater than in K‐NPSCC (60.3%).…”

Section: Discussionsupporting

confidence: 88%

Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes

Vázquez

Khan

Govindaraj

et al. 2014

Int Forum Allergy Rhinol

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Section: Discussionsupporting

confidence: 88%

Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes

Vázquez

Khan

Govindaraj

et al. 2014

Int Forum Allergy Rhinol

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“…Nonkeratinizing NPCs are relatively more frequent in high-incidence areas, where they represent >95 % of all NPCs (compared with approximately 75 % of NPCs in low-incidence areas). Nonkeratinizing NPCs also have a high association with positive EBV serologies, are more radiosensitive, and are more frequently associated with lymph node and distant metastasis (Peterson et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Pathological Profile of Nasopharyngeal Carcinoma in Anatomical Pathology of DR Soetomo General Academic Hospital During 1 January 2016 – 31 December 2018

Fitriyah¹,

Kusumastuti²

2021

IJRP

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Nasopharyngeal carcinoma (NPC) is a malignancy that has unique epidemiological characteristics, which incidence varying according to race and geographical differences. The early stage of NPC is often difficult to diagnose clinically because of its hidden location in the nasopharynx and because the initial symptoms resemble an upper respiratory tract infection. Most of the patients diagnosed at an advanced stage. The aim of this study was to determine the profile nasopharyngeal carcinoma in anatomical pathological Dr. Soetomo General Academic Hospital during 1 January 2016 -31 December 2018. This study used a descriptive observational study with a retrospective approach. The data were presented in tables of the distribution of the number of cases, histopathological diagnosis, sex group, age, chief complaints and follow-up based on histopathology. The data was obtained from the electronic medic record (EMR) of Dr. Soetomo General Academic Hospital. There were 431 cases, the most age was 41-50 years, namely 146 cases (33,9%), the most gender was male consist of 302 cases (70%), the most common complaint was a neck lump, 202 cases (47%), non keratinizing squamous cell carcinoma, undifferentiated subtype was the most histopathological type, namely 398 cases (92,3%), and there were 118 cases (27,3%) who were followed up biopsy, 86 patients (20%) with good respon biopsy results, 21 patients (4,9%) with poor respon biopsy results and 11 patients (2,5%) recurrences.

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“…This is due to the influence of this distinction on prognosis of these tumours, with non-keratinising being more radiosensitive 12. The presence of keratin is associated with reduced local control and survival 13…”

Section: Discussionmentioning

confidence: 99%

Large retropharyngeal abscess: a case of mistaken identity

et al. 2016

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We report an unusual case of nasopharyngeal carcinoma (NPC), presenting initially as a retropharyngeal collection. We discuss the investigation, diagnosis and management of NPC and furthermore review the literature of NPC, emphasising the varied presentation. A 44-year-old Caucasian male ex-smoker presented with a 10-day history of a painless left-sided neck lump; progressive dysphagia and unintentional weight loss. Examination demonstrated a large left posterior pharyngeal swelling with soft palatal effacement, confirmed on nasoendoscopy. A CT scan revealed a fluid collection in the retropharyngeal space, which partially occluded the nasopharynx, and numerous satellite lesions were identified along with cervical lymphadenopathy. The suspected abscess was drained in theatre and nasopharyngeal biopsies were taken. These revealed Epstein-Barr virus-positive NPC. Staging investigations revealed a T4N2M0l carcinoma. Treatment consisted of radical chemoradiation therapy with curative intent. NPC is known for its varied and late presentation, and is an important condition to be aware of when considering a differential diagnosis of pharyngeal masses.

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Nonkeratinizing Undifferentiated Nasopharyngeal Carcinoma

Cited by 16 publications

References 5 publications

Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes

Nasopharyngeal squamous cell carcinoma: a comparative analysis of keratinizing and nonkeratinizing subtypes

Pathological Profile of Nasopharyngeal Carcinoma in Anatomical Pathology of DR Soetomo General Academic Hospital During 1 January 2016 – 31 December 2018

Large retropharyngeal abscess: a case of mistaken identity

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