Active suspension control strategies are a top priority in active suspension system. The current research on active suspension control strategies is mostly focused on two-axle vehicles, and there is less research investigating multi-axle vehicles. Additionally, their effective implementation is dependent on accurate mathematical models, and most of them adopt force feedback control, which is vulnerable to external interference. To solve these problems, this paper proposes an active suspension control strategy based on Inertial Measurement Unit. The multi-axle emergency rescue vehicle is made to be equivalent to a 3-degrees-of-freedom parallel mechanism by using the method of grouping and interconnecting the suspension units of the whole vehicle. The attitude change of the vehicle body was transformed into the servo actuator’s displacement by solving the inverse solution of the parallel mechanism position and the action of the servo actuator was driven in reverse according to the displacement obtained. In this way, the vehicle body attitude can be compensated, and the ride comfort and the handling stability of the vehicle can be improved. To verify the effectiveness of the control strategy proposed, the three-axle six vehicle was taken as the research object, the position inverse solution of its equivalent 3-degrees-of-freedom parallel mechanism was deduced, and a high-pass filter was designed. The three-axle vehicle experiment platform integrating active suspension and hydro-pneumatic suspension was built, and the gravel road and slope road experiments were carried out and the results compared with those obtained with hydro-pneumatic suspension. The experiment results showed that, compared with hydro-pneumatic suspension, the active suspension control strategy based on Inertial Measurement Unit proposed in this paper can not only stabilize the body attitude, but also effectively suppress body vibration, improving the ride comfort and handling stability of the vehicle significantly.