Based on Euler–Bernoulli beam theory, first, partial differential equations were established for the vibration of multiple simply supported beams subjected to moving loads. Then, integral transforms were conducted on the spatial displacement coordinate and time in the partial differential equations, and the frequency-domain response of multiple simply supported beams subjected to moving loads was obtained. Next, by conducting the corresponding inverse transforms on the displacement frequency-domain responses of multiple simply supported beams, the spatial displacement time-domain responses were obtained. Finally, to validate the analytical method reported in this paper, the dynamic response of a typical double simply supported rail-bridge beam system of high-speed railway in China subjected to a moving load was carried out. The results show that the analytical solution proposed in this paper is consistent with the results obtained from a finite element analysis, validating and rationalizing the analytical solution. Moreover, the system parameters were analyzed for the dynamic response of double simply supported rail-bridge beam system in high-speed railway subjected to a moving load with different speeds; the conclusions can be beneficial for engineering practice.