When tubing is in a high-temperature and high-pressure environment, it will be affected by the impact of non-constant fluid and other dynamic loads, which will easily cause the tubing to vibrate or even resonate, affecting the integrity of the wellbore and safe production. In the structural modal analysis of the tubing, the coupling effect of the fluid and the tubing needs to be considered at the same time. In this paper, a single tubing is taken as an example to simulate and analyze the modal changes of the tubing under dry mode and wet mode respectively, and the effects of fluid solid coupling effect, inlet pressure, and ambient temperature on the modal of the tubing are discussed. After considering the fluid–structure interaction effect, the natural frequency of tubing decreases, but the displacement is slightly larger. The greater the pressure in the tubing, the greater the equivalent stress on the tubing body, so the natural frequency is lower. Furthermore, after considering the fluid–solid coupling effect, the pressure in the tubing is the true pulsating pressure of the fluid. The prestress applied to the tubing wall changes with time, and the pressures at different parts are different. At this time, the tubing is changed at different frequencies. Vibration is prone to occur, that is, the natural frequency is smaller than the dry mode. The higher the temperature, the lower the rigidity of the tubing and the faster the strength attenuation, so the natural frequency is lower, and tubing is more prone to vibration. Both the stress intensity and the elastic strain increase with the increase of temperature, so the displacement of the tubing also increases.