Recent studies have shown the importance of including the seismic input directionality in nonlinear analyses for an accurate prediction of the structural demand on frame structures. This paper proposes a new method that includes the multi-directionality of the input seismic forces in Nonlinear Static Analyses (NSAs). Conventionally, the pushover (PO) analyses apply monotonically increasing lateral loads in two directions that typically correspond with the building X and Y directions, that in the case of a rectangular plan are parallel to the building sides. Since in general the direction of the seismic input is a priori unknown, the effects of applying the PO load patterns along varying angles are studied in this paper. Two non-code-conforming reinforced concrete buildings are used as a case study. They have identical structural design but the first one is doubly symmetric while the second one has a significant plan asymmetry due to the translation of the center of mass. PO loads are applied to both structures at angles between 0° and 360° with 15° increments. The results of the NSAs are compared with those of multi-directional NHAs applied at the same angles. The structural demands show that the multi-directional NSAs are more conservative than the conventional NSAs, especially at the corners of the asymmetric- plan building where they can yield significantly higher demands. The base shear capacities in the X and Y directions decrease for intermediate angles due to the interaction between the responses in the X and Y directions that can be captured thanks to the columns’ fiber section discretization. On average the results of the multi-directional NSAs are closer to those of the NHAs, even though they are generally lower.