A preliminary assessment is developed for long time record modeling and simulation of coupled flow-structural response of thin-gauge panels subject to shock impingements. The study is based on a set of recent discovery experiments carried out by the Air Force Research Laboratory. The fluid loads are modeled using a CFD surrogate for the steady surface pressure combined with engineering level approximations for unsteady pressure fluctuations due to panel vibration and boundary layer turbulence. The structure is modeled using both full-order and reduced-order finite element formulations. Initial comparisons indicate reasonable confidence in modeling the steady component of pressure and structural modeling, and less confidence in modeling the fluctuating pressure and dynamic panel response. Several sources of modeling and measurement uncertainties are highlighted.