Abstract. We revise the classical approach by Brézis-Gallouët to prove global well posedness for nonlinear evolution equations. In particular we prove global well-posedness for the quartic NLS posed on general domains Ω in R 2 with initial data in H 2 (Ω)∩H 1 0 (Ω), and for the quartic nonlinear half-wave equation on R with initial data in H 1 (R).The main aim of this paper is to revise the technique developed by Brézis-Gallouët to study the global well-posedness of Cauchy problems associated with some nonlinear evolution equations. We prove that by the Brézis-Gallouët technique applied to higher order energy with integration by parts, the standard theory developed in [5] and [18] for NLS and half-wave equation with cubic nonlinearity, has an improvement to quartic nonlinearity.Our first result concerns an extension to higher order nonlinearities of the very classical result in [5]. More precisely the first family of problems that we shall address is the following one:where λ = ±1, Ω ⊂ R 2 is open and satisfies the following hypothesis:is self-adjoint . By the celebrate Brézis-Gallouët inequality it follows that if Ω satisfies (H1), then the following logarithmic Sobolev embedding occurs:There has been a growing interest in the last decades on the Cauchy problem associated with NLS on domains, starting from the pioneering paper [5]. In this paper the authors can deduce global well-posedness for the defocusing cubic NLS on domains Ω ⊂ R 2 , by combining (0.2) with the conservation of the energy. A first extension of the result by Brézis-Gallouët, up to the fourth order nonlinearity, was obtained in [21] under some restrictive conditions on the initial data ϕ. More precisely it is assumed ϕ|ϕ| ∈ H 3 (Ω) ∩ H 1 0 (Ω), ∆ϕ ∈ H 1 0 (Ω). A fundamental tool to treat NLS on domains, with higher order nonlinearities, are the so called Strichartz inequalities (see [8] and the bibliography therein for the case Ω = R 2 ). In [6] it is proved a suitable version of Strichartz inequalities with loss, on general compact manifolds. Beside other results in this paper it is studied the Cauchy problem Due to the huge literature devoted to NLS on 2D domains, Theorem 0.1 below could be considered somewhat weaker compared with the known results, however we prefer to keep its statement along this paper for three reasons. First of all our argument is exclusively based on integration by parts and energy estimates, and hence it is independent on the use of Strichartz estimates. The second reason is that the proof of Theorem 0.1 can help to understand the idea behind the more involved proof of our second result concerning the nonlinear half-wave equation, where as far as we know our result is a novelty in the literature. The third reason is that as far as we know it is unclear whether or not the aforementioned Strichartz estimates are available under the rather general assumptions (H1), (H2).Let us recall that by the usual energy estimates, in conjunction with the classical Sobolev embedding H 2 (Ω) ֒→ L ∞ (Ω), one can prove that the Cauchy ...