The seismic performance and damage pattern of the split-foundation frame buildings in across-slope direction are studied. In view of the characteristics of split-foundation structure, the parameter analyses of split-foundation structure with different spans and floors of lower and upper parts are studied, and the main factors affecting the torsional effect of split-foundation structure are also studied theoretically. Finally, the improvements and design procedure of split-foundation structure are put forward to reduce the difference in ductility demands between the upper ground columns and the lower part. Results show that the torsional effect of split-foundation structure is very significant because of the rigidity eccentric. The upper ground columns are the weakest parts of split-foundation structure which are destroyed first under the earthquake action; then, the lower floors are destroyed in succession. Lower ductility demands of the upper ground columns and better seismic performance of the split-foundation structure can be achieved by the designed improvements.