Nonmotor Symptoms in Nursing Home Residents with Parkinson's Disease: Prevalence and Effect on Quality of Life

Weerkamp, Nico J.; Tissingh, Gerrit; Poels, P.J.E.; Zuidema, S U; Munneke, Marten; Koopmans, Raymond T.C.M.; Bloem, Bastiaan R.

doi:10.1111/jgs.12458

Cited by 64 publications

(49 citation statements)

References 48 publications

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“…This study was carried out in ambulatory patients treated in primary care facilities, in an early disease stage. In populations of late-stage PD patients living in nursing care facilities, 77 % of patients were found to meet criteria for PD-related dementia, and besides cognitive complaints, depression and poor nighttime sleep were also found frequently [13]. Gender differences have also been described.…”

Section: Discussionmentioning

confidence: 96%

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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Parkinson's disease (PD) is a multisystem disorder, and besides the classical motor symptoms it is now known that patients also suffer from a variety of non-motor symptoms that adversely affect quality of life (QOL). Since data on Hispanic populations on this issue are scarce, our aim was to study the association of non-motor symptoms and QOL in patients with PD. This study is a cross-sectional observational study involving patients with PD using the following instruments: Quality of Life Questionnaire (PDQ-8), Unified Parkinson's Disease Rating Scale part III (UPDRS part III), and Non-Motor Symptom Scale (NMSS). We included 52 patients, with a median age of 64 years. Sleep/fatigue and mood/cognitive domains were the most common non-motor symptoms. Only sleep/fatigue, mood/cognition and gastrointestinal domains were associated with worse PDQ-8 scores. After adjusting for confounding variables, NMSS scores were significantly associated with a high PDQ-8 score. Higher NMSS scores were associated with and predicted higher PDQ-8 scores. The focus of management in PD should shift to a comprehensive strategy that incorporates care of non-motor symptoms and improves QOL.

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Section: Discussionmentioning

confidence: 96%

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

et al. 2015

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“…This study is first of all mainly focused on patients with PD living independently at home. Two patients in a nursing home were spoken to and it was decided not to include more nursing home patient as their perceptions on QoL had already been studied [39]. However, when comparing the member check reports of the PD patients living in a nursing home with other participants in the study, it was concluded that their perceptions might not vary much.…”

Section: Discussionmentioning

confidence: 97%

Quality-of-life of patients with Parkinson’s disease

Dauwerse¹,

Hendrikx²,

Schipper³

et al. 2014

Brain Injury

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“…Another study demonstrated that PD patients with Hoehn &Yahr stage 4 had significantly more daytime sleepiness than stages 1, 2, or 3, without group differences for dopaminergic therapy[301]. In a study of non-motor symptoms in nursing home residents with PD, 68% reported daytime sleepiness[295], supporting the idea that EDS is related to disease duration and severity.…”

Section: Excessive Daytime Sleepinessmentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

272

249

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Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

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Nonmotor Symptoms in Nursing Home Residents with Parkinson's Disease: Prevalence and Effect on Quality of Life

Abstract: Nonmotor symptoms were highly prevalent in NH residents with PD. Quality of life was poor, largely because of NMS. Because many NMS are potentially treatable, diagnosis and treatment of these severely affected individuals deserve more attention.

Cited by 64 publications

References 48 publications

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico

Quality-of-life of patients with Parkinson’s disease

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

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