Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells

Azad, Meghan B.; Archibald, Alyssa; Tomczyk, Mateusz M; Head, Alanna; Cheung, Kyle; Souza, Russell J. de; Becker, Allan B.; Mandhane, Piushkumar J.; Turvey, Stuart E.; Moraes, Theo J.; Sears, Malcolm R.; Subbarao, Padmaja; Dolinsky, Vernon W.

doi:10.1038/s41366-020-0575-x

Cited by 41 publications

(40 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prenatal maternal consumption of non-nutrient sweeteners (19) May alter maternal microbiome and therefore microbiome transmitted to offspring after birth. Association with obesogenic effects on offspring is possible.…”

Section: Factors Of Nutrition During Pregnancymentioning

confidence: 99%

Impact of Early Life Nutrition on Children’s Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome

et al. 2021

View full text Add to dashboard Cite

The first 1000 days of life, including the intrauterine period, are regarded as a fundamental stepping stone for the development of a human. Unequivocally, nutrition during this period plays a key role on the proper development of a child, both directly through the intake of essential nutrients and indirectly by affecting the composition of the gut microbiota. The gut microbiota, including bacteria, viruses, fungi, protists and other microorganisms, is a highly modifiable and adaptive system that is influenced by diet, lifestyle, medicinal products and the environment. Reversely, it affects the immune system in multiple complex ways. Many noncommunicable diseases (NCDs) associated with dysbiosis are “programmed” during childhood. Nutrition is a potent determinant of the children’s microbiota composition and maturation and, therefore, a strong determinant of the NCDs’ programming. In this review we explore the interplay between nutrition during the first 1000 days of life, the gut microbiota, virome and mycobiome composition and the development of NCDs.

show abstract

Section: Factors Of Nutrition During Pregnancymentioning

confidence: 99%

Impact of Early Life Nutrition on Children’s Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Based on NIH quality assessment, six studies had good quality (5,6,20,43,45,46) , three studies were of fair quality (21,42,44) and two had poor quality (42,47) . The common sources of bias were information bias (21,42,45,46) and selection bias (5,6,20,21,42,(42)(43)(44)47) , which included the exposure assessed only once over time and loss to follow-up (see online supplementary material, Supplemental Table 2).…”

Section: Quality Assessment and Certainty Assessmentmentioning

confidence: 99%

Effects of prenatal artificial sweeteners consumption on birth outcomes: a systematic review and meta-analysis

Cai

Sivak

Davenport

2021

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To examine the influence of prenatal artificial sweetener consumption on birth outcomes. Design: Systematic review and meta-analysis. Setting: Online databases (MEDLINE, CINAHL, EMBASE, Cochrane Library, Scopus, Web of Science, FSTA - the food resource database, and ClinicalTrials.gov) were searched up to April 9, 2020. Studies of all designs (except case studies and reviews) were eligible, which contained information on the relevant population (pregnant women), intervention/exposure (any artificial sweeteners consumption), comparator (no artificial sweetener consumption), and birth outcomes (preterm delivery, gestational age, birth weight). Results: From 677 citations, ten cohort studies and one randomized controlled trial (n=138,007 women) were included. “Low” to “very low” certainty evidence revealed that daily consumption of artificial sweeteners was associated with an increased risk of preterm delivery (three studies, n=129,009; risk ratio=1.18, 95% CI: 1.09 to 1.28, I2=9%), a 24 g increase in birth weight (three studies, n=64,417; mean difference [MD]: 23.74 g, 95% confidence interval [CI]: 0.89 to 45.58, I2=0%), and a 0.11 week decrease in gestational age (three studies, n=64,417; MD:-0.11 weeks, 95% CI: -0.19 to -0.03, I2=0%). Conclusion: “Low” to “very low” certainty evidence suggests daily AS consumption during pregnancy is associated with an increased risk of preterm delivery, increased birth weight and decreased gestational age. Additional “high” quality research is urgently needed to further assess these relationships. PROSPERO registration number: CRD42019136728

show abstract

“…Animal studies indicate that acesulfame-K crosses the placenta during pregnancy and can potentially lead to an increased sweet preference during adulthood (215). On the other hand, prenatal sucralose exposure does not affect fetal organogenesis (216), but increases the risk for hematopoietic neoplasia in male mice (135) and favors adipocyte differentation in cultured pre-adipocytes (217). These results suggested that non-calorie sweeteners consumption during pregnancy could impact on offspring adipose tissue differentiation, promoting childhood obesity (217).…”

Section: Impact Of Sweeteners On Gut Microbiotamentioning

confidence: 99%

“…On the other hand, prenatal sucralose exposure does not affect fetal organogenesis (216), but increases the risk for hematopoietic neoplasia in male mice (135) and favors adipocyte differentation in cultured pre-adipocytes (217). These results suggested that non-calorie sweeteners consumption during pregnancy could impact on offspring adipose tissue differentiation, promoting childhood obesity (217). Moreover, exposure of pregnant mice to a mixture of acesulfame-K and sucralose at different concentrations demonstrated that non-calorie sweeteners were able to affect gut microbiota composition in the offspring in a dose-dependent manner, increasing Firmicutes content and reducing the amount of beneficial species, including Akkermansia muciniphila (218).…”

Section: Impact Of Sweeteners On Gut Microbiotamentioning

confidence: 99%

Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

et al. 2020

View full text Add to dashboard Cite

Since excessive sugar consumption has been related to the development of chronic metabolic diseases prevalent in the western world, the use of sweeteners has gradually increased worldwide over the last few years. Although low-and non-calorie sweeteners may represent a valuable tool to reduce calorie intake and prevent weight gain, studies investigating the safety and efficacy of these compounds in the short-and long-term period are scarce and controversial. Therefore, future studies will need to elucidate the potential beneficial and/or detrimental effects of different types of sweeteners on metabolic health (energy balance, appetite, body weight, cardiometabolic risk factors) in healthy subjects and patients with diabetes, obesity and metabolic syndrome. In this regard, the impact of different sweeteners on central nervous system, gut hormones and gut microbiota is important, given the strong implications that changes in such systems may have for human health. The aim of this narrative review is to summarize the current evidence for the neuroendocrine and metabolic effects of sweeteners, as well as their impact on gut microbiota. Finally, we briefly discuss the advantages of the use of sweeteners in the context of very-low calorie ketogenic diets.

show abstract

Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells

Cited by 41 publications

References 44 publications

Impact of Early Life Nutrition on Children’s Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome

Impact of Early Life Nutrition on Children’s Immune System and Noncommunicable Diseases Through Its Effects on the Bacterial Microbiome, Virome and Mycobiome

Effects of prenatal artificial sweeteners consumption on birth outcomes: a systematic review and meta-analysis

Neuroendocrine and Metabolic Effects of Low-Calorie and Non-Calorie Sweeteners

Contact Info

Product

Resources

About