Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids for The Management of Canine Osteoarthritis

Johnston, Spencer A.; Budsberg, Steven C.

doi:10.1016/s0195-5616(97)50083-0

Cited by 77 publications

(70 citation statements)

References 78 publications

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“…Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used for the treatment of musculoskeletal disease in veterinary medicine, and are generally recognized for their analgesic, antipyretic, and anti-inflammatory properties [18,20]. These effects are in general mediated by the inhibition of inflammatory cyclooxygenase (COX-2).…”

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confidence: 99%

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Narita

Tomizawa

Sato

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the adverse effects of long-term administration of ketoprofen in dogs, ketoprofen (1 mg/kg) was administered to five clinically healthy beagle dogs (ketoprofen group) and gelatin capsules (control group) were administered to four clinically healthy beagle dogs for 30 days. We monitored the dogs through periodic physical examination, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests, urinalysis, urinary enzyme indices and cuticle bleeding time analysis. The lesions in the stomach, especially in the pyloric antrum, and fecal occult blood progressively worsened in the ketoprofen group. However, the differences between the ketoprofen group and the control group were not statistically significant. One dog in the ketoprofen group temporarily exhibited a decrease in renal plasma flow and two dogs exhibited enzymuria. However, these changes did not persist and the other examinations showed no significant difference between premedication and postmedication in the ketoprofen group. Therefore, the adverse effects of long-term administration of ketoprofen observed in this study were not clinically important in healthy dogs. Nevertheless, further investigation of adverse renal effects from long-term administration of ketoprofen is necessary in the dogs with subclinical renal disease. KEY WORDS: adverse effect, canine, Ketoprofen, long-term administration.

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confidence: 99%

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Narita

Tomizawa

Sato

et al. 2005

The Journal of Veterinary Medical Science

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“…Corticosteroids can affect PG synthesis in several tissues, via a strong blockade at the level of mRNA transcription for COX-2 [8,29] and a weak blockade at the level of mRNA transcription for COX-1 [38], and the inhibition of phospholipase A 2 [2] that synthesizes arachidonic acid from phospholipid [18]. Therefore, corticosteroids, even a low dosage of prednisolone (0.5 mg/kg), are thought to aggravate gastric mucosal adverse effects of reduced dosage ketoprofen (0.25 mg/kg) via the blockade of COX-2 expression and the inhibition of phospholipase A 2 .…”

Section: Disccusionmentioning

confidence: 99%

“…Non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used for the management of chronic pain due to inflammatory joint disease in dogs [15,18,32]. The analgesic and anti-inflammatory effects of NSAIDs have been attributed to the prevention of prostaglandin (PG) synthesis from arachidonic acid, through inhibition of cyclooxygenase (COX) [18].…”

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confidence: 99%

“…The analgesic and anti-inflammatory effects of NSAIDs have been attributed to the prevention of prostaglandin (PG) synthesis from arachidonic acid, through inhibition of cyclooxygenase (COX) [18]. Two isoenzymes of COX (COX-1 and COX-2) have been identified.…”

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confidence: 99%

“…Corticosteroids, such as prednisolone, are also commonly used in several inflammatory diseases, including osteoarthritis [18], and are well known to cause gastric mucosal injury in dogs [34,35]. Clinically, NSAIDs and corticosteroids are frequently used alone.…”

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confidence: 99%

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The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Narita

Sato

Motoishi

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. The interaction between oral non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone administered concurrently for 30 days was studied in 18 healthy dogs divided into 3 groups of 6 dogs each: a drug-free negative control group (NC group) given 2 gelatin capsules; a group given meloxicam (0.1 mg/kg) and prednisolone (0.5 mg/kg) (MP group); and a group given a reduced dosage of ketoprofen (0.25 mg/kg, PO) and prednisolone (0.5 mg/kg, PO) (KP group). The dogs were periodically monitored by physical examinations, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests [effective renal plasma flow (ERPF) and glomerular filtration rate (GFR)], urinalyses [urinary sediments, and urinary micro-albumin to creatinine ratio (UAlb/Cre)], urinary enzyme indices, and haemostatic function tests [buccal mucosa bleeding time (BMBT), cuticle bleeding time (CBT)]. Significant changes were observed in the KP group, including a decrease of ERPF and GFR, an increased UAlb/Cre ratio, prolonged BMBT and CBT, as well as the presence of more severe grades of endoscopic lesions and fecal occult blood. In both the MP and KP groups, abnormal enzymuria with exfoliation of renal tubular epithelial cells in the urine was found. However, no significant changes in any of the other tests were observed in the MP group compared with the NC group. These findings suggest that the combination of NSAIDs, even selective COX-2 inhibitors, with prednisolone may be contraindicated due to the potential for serious adverse effects on the kidneys, the platelets, and the gastrointestinal tract.

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Gastrointestinal Tract

2012

Comparative Pathophysiology and Toxicology of Cyclooxygenases

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Nonsteroidal Anti-Inflammatory Drugs and Corticosteroids for The Management of Canine Osteoarthritis

Cited by 77 publications

References 78 publications

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

Effects of Long-Term Oral Administration of Ketoprofen in Clinically Healthy Beagle Dogs

The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Gastrointestinal Tract

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