2007
DOI: 10.1292/jvms.69.353
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The Interaction between Orally Administered Non-Steroidal Anti-Inflammatory Drugs and Prednisolone in Healthy Dogs

Abstract: ABSTRACT. The interaction between oral non-steroidal anti-inflammatory drugs (NSAIDs) and prednisolone administered concurrently for 30 days was studied in 18 healthy dogs divided into 3 groups of 6 dogs each: a drug-free negative control group (NC group) given 2 gelatin capsules; a group given meloxicam (0.1 mg/kg) and prednisolone (0.5 mg/kg) (MP group); and a group given a reduced dosage of ketoprofen (0.25 mg/kg, PO) and prednisolone (0.5 mg/kg, PO) (KP group). The dogs were periodically monitored by physi… Show more

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Cited by 39 publications
(20 citation statements)
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“…; Narita et al . ). Evidence supporting NSAID administration as a cause of equine glandular gastric ulceration syndrome (EGGUS) at a population level is weak (Sykes and Jokisalo ).…”
Section: Discussionmentioning
confidence: 97%
“…; Narita et al . ). Evidence supporting NSAID administration as a cause of equine glandular gastric ulceration syndrome (EGGUS) at a population level is weak (Sykes and Jokisalo ).…”
Section: Discussionmentioning
confidence: 97%
“…Administration of NSAIDs with corticosteroids can significantly increase the risk of gastrointestinal toxicity. The combination of prednisolone with either ketoprofen or meloxicam resulted in considerable adverse effects on the kidney, gastrointestinal mucosa and platelet function in dogs (Narita et al. 2007).…”
Section: Adverse Class‐effects Of Nsaidsmentioning
confidence: 99%
“…Urinary NAG (uNAG) has proven to be a useful tool in early detection of renal injury in various human diseases as reviewed by Skalova 11 . In veterinary medicine, an increased uNAG‐to‐creatinine ratio (uNAG/c) has been observed in dogs in various stages of CKD, 12,13 leishmaniasis, 14 and pyometra 13,15 and in dogs treated with nephrotoxic antibiotics, 16 NSAIDS, or glucocorticoids 17 …”
mentioning
confidence: 99%
“…11 In veterinary medicine, an increased uNAG-to-creatinine ratio (uNAG/c) has been observed in dogs in various stages of CKD, 12,13 leishmaniasis, 14 and pyometra 13,15 and in dogs treated with nephrotoxic antibiotics, 16 NSAIDS, or glucocorticoids. 17 Most studies in dogs have focused on 1 urinary marker, whereas reports on the combined measurement of glomerular and tubular markers in healthy and CKD dogs are scarce. Data about urinary marker assay validation likewise are scarce, especially for NAG.…”
mentioning
confidence: 99%