Nonsteroidal Anti-Inflammatory Drugs and Their Effects in the Elderly

Abstract

Management of chronic pain can often be a challenging task, especially in the elderly. Patients over the age of 65 years have altered metabolism and pharmacodynamics that increase their susceptibility to adverse side effects. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a common component of pain management in this population. Nonselective NSAIDs as well as selective Cox-2 inhibitors have been associated with side effects, including renal dysfunction, heart failure, gastrointestinal toxicity and increased risk of cardiovascular side effects. These adverse effects are particularly important in the elderly, and thus use of NSAIDs in this population must be scrutinized carefully. If NSAIDs are utilized, they should be tailored to the individual patient and administered in the lowest dose and for the shortest duration possible. It is hoped that future studies will provide further insight into the safety of these agents in elderly patients.

Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

“…Thus, NSAIDs with little or no effect on COX-2, such as aspirin, rarely cause obvious sodium retention and hypertension. 18 In the SUCCESS VI and VII trials, there was a significant increase in the number of patients with high blood pressure in an elderly population (> 65 years), using coxibs, especially rofecoxib. 19 , 20 …”

Nem szteroid gyulladáscsökkentők peroralis és transdermalis alkalmazása regionális mozgásszervi fájdalmi szindrómákban

“…A kritikátlan vagy hibás tájékoztatáson alapuló öngyógyszerelés, a környezet és a gyógyítóteam esetleges téves tájékoztatása is szerepel a felismerendő kockázatok között. Az idős beteg ellátóinak viszont tisztában kell lennie ezekkel a kockázatokkal, megkülönböztetett figyelemmel kell kísér-nük az idős beteget, aktívan tájékozódniuk kell a beteg korlátai felől és el kell látniuk a biztonságos gyógyszer-szedéshez szükséges információkkal [68][69][70].…”

Users' Knowledge About Adverse Effects of Non-steroidal Anti-inflammatory Drugs in Tirana, Albania

“…Other studies suggest that use of NSAIDs could also increase the risk of lower gastrointestinal bleeding and perforation in a similar way to upper gastrointestinal bleeding, with advanced age, previous history of peptic ulcer and prolonged use being the major risk factors ( 2 ). Other adverse health effects of NSAIDs use include hypertension, renal dysfunction (acute kidney injury, reduced glomerular filtration rate, heart failure and increased risk of death, adverse cardiovascular events including myocardial infarction and stroke ( 4 ). Prolonged use of NSAIDs may also alter and/or impair muscle growth and development ( 5 ).…”