Nonsteroidal Anti-inflammatory Drugs in the Treatment of Pericarditis

Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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“…NSAIDs may be useful in the treatment of acute pain in pericarditis (Schifferdecker & Spodick, 2003).…”

Section: N 2 O In Oxygen Was Effective In Relieving Acute Ischaemic Cmentioning

confidence: 99%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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“…Na pericardite pós-infarto agudo do miocárdio, deve-se evitar o uso de indometacina, por estar relacionada à redução do processo cicatricial da área infartada 224,225 . O tempo de tratamento da pericardite com AINH é em torno de 14 dias, usualmente, podendo ser guiado pelos níveis séricos da PCRT como marcador de atividade inflamatória.…”

Section: Anti-inflamatórios Não Hormonais E Colchicinaunclassified

I Diretriz Brasileira de Miocardites e Pericardites

Montera

Mesquita

Colafranceschi

et al. 2013

Arquivos Brasileiros De Cardiologia

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“…5,7 For example, in a 2004 study without a control group, outpatient therapy of uncomplicated pericarditis with aspirin relieved symptoms in 87% of 254 patients. 5 Commonly used NSAID regimens are listed in the Table, with a recommended initial duration of 7 to 14 days, then treatment should be tapered until resolution of symptoms and improvement of acutely elevated serum inflammatory markers such as C-reactive protein and the erythrocyte sedimentation rate.…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Treatment of Acute and Recurrent Idiopathic Pericarditis

Lilly

2013

Circulation

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Nonsteroidal Anti-inflammatory Drugs in the Treatment of Pericarditis

Cited by 32 publications

References 36 publications

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

I Diretriz Brasileira de Miocardites e Pericardites

Treatment of Acute and Recurrent Idiopathic Pericarditis

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