Nonsurgical management of oropharyngeal, laryngeal, and hypopharyngeal cancer: The Fox Chase Cancer Center experience

Andrews, Genevieve A.; Lango, Miriam; Cohen, Roger B.; Feigenberg, Steven J.; Burtness, Barbara; Mehra, Ranee; Ahmed, Sidrah; Nicolaou, Nicos; Gaughan, John; Ridge, John A.

doi:10.1002/hed.21615

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twenty‐two articles were selected for inclusion and analysis in the study (Table ) . The studies reported on 1105 patients, a mean of 50 patients (range, 5–163) per study, published between 1976 and 2014.…”

Section: Resultsmentioning

confidence: 99%

Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta‐analysis

et al. 2016

View full text Add to dashboard Cite

Background. Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods. A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data.Results. Twenty-two retrospective studies were included. Pooled 3-year overall survival (OS) was 26% (95% confidence interval [CI] 5 22% to 29%; I squared 5 40.7%; p 5 .057). Pooled 5-year OS was 23% (95% CI 5 20% to 27%; I squared 5 73.9%; p 5 .000). Surgical treatment was superior to radiation (5-year OS 26% vs 16%, respectively; p <

show abstract

Section: Resultsmentioning

confidence: 99%

Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta‐analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The differences in OS and progression‐free survival were stark: HRs for death and relapse or death were 0.29 and 0.33, respectively, for patients in the low‐risk group compared to the high‐risk group . The profound effect of HPV on oropharyngeal SCC outcomes has been confirmed in multiple retrospective single institution and nationwide database analyses . Together, these data have led to increased optimism regarding the future of clinical outcomes for patients with oropharyngeal SCC.…”

Section: Discussionmentioning

confidence: 97%

“…3 The profound effect of HPV on oropharyngeal SCC outcomes has been confirmed in multiple retrospective single institution and nationwide database analyses. [2][3][4]6,8,[10][11][12][13] Together, these data have led to increased optimism regarding the future of clinical outcomes for patients with oropharyngeal SCC.…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes

et al. 2015

View full text Add to dashboard Cite

Background A significant fraction of OPSCCA cases is associated with traditional carcinogens; in these patients treatment response and clinical outcomes remain poor. Methods We evaluated patient, tumor and treatment characteristics for 200 veterans with OPSCCA treated at the Michael E. DeBakey Veterans Affairs Medical Center (MEDVAMC) between 2000 and 2012. Results Most patients (77%) were white and heavy smokers. Twenty seven patients required tracheostomy and 63 required gastrostomy placement during treatment. Overall survival at 5 years was 40%.. Survival was impacted by T stage, treatment intensity, completion of treatment and p16 tumor status. Almost 30% of patients were unable to complete a treatment regimen consistent with NCCN guidelines. Conclusions OPSCCA in veterans is associated with traditional carcinogens and poor clinical outcomes. Despite heavy smoking exposure, p16 tumor status significantly impacts survival. Careful consideration must be given to improving treatment paradigms for this cohort given their limited tolerance for treatment escalation.

show abstract

Survival analysis of 287 oropharyngeal squamous cell carcinoma patients in a single institution: a retrospective comparison of two consecutive time intervals with surgical and conservative treatment approaches

Münscher

Bußmann

Sehner

et al. 2017

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated. Main outcome measures were overall survival (OS) and recurrence-free survival (RFS). Between 2002 and 2007, early-stage OPSCC showed a 5-year OS of 75% compared to that of 86% between 2008 and 2013. Locally advanced OPSCC showed a 5-year OS of 66% between 2002 and 2007 compared to that of 74% between 2008 and 2013. RFS in early-stage OPSCC was 48% between 2002 and 2007 in contrast to that of 77% between 2008 and 2013. With locally advanced OPSCC, RFS was 55% between 2002 and 2007 compared to that of 56% between 2008 and 2013. These differences were statistically not significant. The OS and RFS remained generally unchanged over the analysed time period. There was no significant difference in the outcomes with regards to HPV status and to their treatment modality.

show abstract

Nonsurgical management of oropharyngeal, laryngeal, and hypopharyngeal cancer: The Fox Chase Cancer Center experience

Cited by 5 publications

References 17 publications

Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta‐analysis

Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta‐analysis

Oropharyngeal squamous cell carcinoma in the veteran population: Association with traditional carcinogen exposure and poor clinical outcomes

Survival analysis of 287 oropharyngeal squamous cell carcinoma patients in a single institution: a retrospective comparison of two consecutive time intervals with surgical and conservative treatment approaches

Contact Info

Product

Resources

About